An Overview Of Nonalcoholic Fatty Liver Disease

Table of Contents

Introduction

The digestive system is home to many of the organs that help digest food into vitamins and nutrients and has a bidirectional with the central nervous system. The organs that consist in the digestive system include the stomach, the intestines (both large and small), and the liver to name a few. When there are unwanted factors and pathogens that enter through the mouth and into the digestive system can cause problems and unwanted symptoms like inflammation, leaky gut, and nonalcoholic fatty liver disease (NAFLD) pop up over time causing a person to be in pain. In this article, we will be taking a look at what the liver does in the body, what is NAFLD and its symptoms, as well as some treatments to prevent NAFLD’s effects on the body from rising. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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What Does The Liver Do?

About the size of a football, the liver is a reddish-brown wedge-shaped organ that has many functions that help the body stay functional. Research studies show that the liver has many physiological processes like macronutrient metabolism, blood volume regulation, immune support, helps control growth signaling pathways for the endocrine system, and many more. Located in the upper right-hand portion of the body and on top of the stomach, the liver is an essential organ that provides proteins and hormones that the other organs need in the body. Other research studies have shown that some of the jobs that the liver does for the body include:

Stores glycogen and vitamins for the body to use later
Make bile fluid to help the body digest food
Cleans toxins out of the blood
Metabolizes proteins, carbohydrates, and fats
Produces substances to help with blood clots

HCTP Therapy

Tony Robbins finds secret to eliminating back pain

Stem cells* or HCTP (human cellular tissue products) are used in both affiliated clinics and distribution organizations as a form of regenerative cellular treatments to help boost the body’s own natural healing process. Some of the beneficial properties that HCTP provides to the body is that it helps repair and regenerate damaged cells, diseased organs, and tissues back to their original state and function in the body. With much more upcoming research on the benefits that HCTP provides to the body, many individuals can begin to feel better and continue on their wellness journey pain-free.

What Is NAFLD?

NAFLD or nonalcoholic fatty liver disease is a range of liver conditions that affect the liver. Research studies have shown that NAFLD has several phases of progressions in the body since it has a benign course as a silent liver disease due to the presence of hepatic injury with inflammation. Since 3-6 million Americans with viral hepatitis don’t know they are infected with NAFLD, there could be many factors that can lead to the progression of NAFLD. In 2004, the National Institute of Health estimated the annual costs in the US of chronic liver disease and cirrhosis is $1.6 billion. However, the most recent estimates of the population with liver disease in the US range from 15 to 30 million, indicating that the annual cost may range from $5 to $10 billion. Other studies have found that NAFLD is a growing pandemic worldwide due to obesity and insulin resistance that can lead the liver to accumulate triglycerides and free fatty acids in the body.

The Symptoms

Research studies show that in most cases fatty liver diseases don’t cause any serious problems or prevent the liver from functioning properly unless the person has it and the disease gets worse over time as it progresses in three stages. The first stage is known as steatohepatitis, where the liver becomes inflamed causing tissue damage. The second stage is fibrosis, where scar tissues begin to form on the damaged areas of the liver. And finally, the third stage is cirrhosis, where there is extensive scar tissue replacing the healthy liver tissues. Other symptoms that NAFLD can cause in the body include:

Abdominal pain
Nausea
Jaundice
Edema

How To Treat Liver Disease?

There are ways to prevent liver disease from progressing further in the liver and can be reversed when there is a sign of early liver damage. The amazing thing about the liver is that it has the ability to repair itself and utilize different treatments to prevent progressive liver disease from causing further damage. Research studies have shown that lifestyle interventions, pharmacological therapy, exercise, and caloric restrictions are beneficial to treat liver disease.

Exercise

Doing any sort of exercise is beneficial not only for the body but also for the liver. Research studies show that when a person exercises, there will be an increase in fatty acid oxidation, a decrease in fatty acid synthesis, and mitochondrial and hepatocellular damage will be prevented and reduced. Physical exercises can improve fatty liver disease and help individuals lose weight, lower their insulin and reduce the excess free fatty acids. Another beneficial property that physical activity can provide to individuals is that it can improve their moods and stop neurological disorders from progressing as well. Other research studies have shown that with the combination of calories restriction, physical activity can effectively decrease the intrahepatic lipid component.

Conclusion

All in all, the liver is part of the digestive system where it sends out nutrients and vitamins to the entire body. When there are unwanted pathogens that enter through the mouth and disrupt the digestive system, it can cause chronic symptoms like inflammation and nonalcoholic fatty liver disease and damage the liver. Since NAFLD is a chronic progressive disease, by incorporating treatments like eating healthy, exercising, and taking supplements can help people be pain-free on their wellness journey.

References

Beaton, Melanie D. “Current Treatment Options for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.” Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie, Pulsus Group Inc, June 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3378283/.

Benedict, Mark, and Xuchen Zhang. “Non-Alcoholic Fatty Liver Disease: An Expanded Review.” World Journal of Hepatology, Baishideng Publishing Group Inc, 8 June 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5468341/.

Berzigotti, Annalisa, et al. “Physical Activity and Liver Diseases.” Hepatology (Baltimore, Md.), U.S. National Library of Medicine, Mar. 2016, pubmed.ncbi.nlm.nih.gov/26313307/.

Kudaravalli, Pujitha, and Savio John. “Nonalcoholic Fatty Liver.” StatPearls [Internet]., U.S. National Library of Medicine, 19 July 2021, www.ncbi.nlm.nih.gov/books/NBK541033/.

Medical Professionals, Cleveland Clinic. “Fatty Liver Disease: Risk Factors, Symptoms, Types & Prevention.” Cleveland Clinic, 31 July 2020, my.clevelandclinic.org/health/diseases/15831-fatty-liver-disease.

Medical Professionals, Cleveland Clinic. “Liver: What It Does, Disorders & Symptoms, Staying Healthy.” Cleveland Clinic, 22 Feb. 2021, my.clevelandclinic.org/health/articles/21481-liver.

Trefts, Elijah, et al. “The Liver.” Current Biology: CB, U.S. National Library of Medicine, 6 Nov. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5897118/.

van der Windt, Dirk J, et al. “The Effects of Physical Exercise on Fatty Liver Disease.” Gene Expression, Cognizant Communication Corporation, 18 May 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5954622.

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An Overview On Different Factors Affecting Gut-Brain Axis | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

The gut and the brain have two different jobs that do different functions in the body but, have a bidirectional communication with each other. The brain is part of the central nervous system that sends out neuron signals all throughout the entire body. These neuron signals make sure that everything is working properly, from the heart beating to blood pressure being regulated. The gut is part of the digestive system and it makes sure that food is being digested properly, while the beneficial good bacteria is protecting the gut from harmful pathogens. When unwanted pathogens start to affect either the brain, the gut, or both, it can cause problems to the body making it dysfunctional and causing the individual unwanted pain. In this 2 part series, we will be taking a look at the different factors that can affect the gut-brain axis. Part 1 took a look at what the gut-brain axis is and how does it function in the body. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

The Gut-Brain Connection

The gut-brain connection provides a bidirectional connection to both the brain and the gut. Both of these organs continuously send each other signals back and forth in order to make sure that the body is functioning properly while also doing their jobs as well. Research studies show that the gut-brain connection is also known as the enteric nervous system and what it does is that it’s a network of nerves, neurons, and neurotransmitters that extends all over the entire digestive tract. The enteric nervous system is also referred to as a “second brain”, which is the gut as it is in constant communication to the brain and plays a major key role in diseases and mental health for individuals.

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) are a form of regenerative cellular treatments that help boost the body’s own natural healing process. HCTP has been used in both international and nationally affiliated clinics and distribution organizations by repairing and regenerating damaged cells, diseased tissues, and organs back to their original state and function in the body. With more upcoming research about the beneficial properties of HCTP, many individuals can get their lives back together pain-free and without chronic issues affecting them.

The Factors That Affect The Gut-Brain

There are many factors that can affect both the gut and the brain as the body does encounter many pathogens that can cause a person to be in pain. Studies have found that gut microbiota has been known to support tight junction integrity and when dysbiosis and increased intestinal permeability can cause dysfunction to the brain. The same goes for the brain when the neuron signals are being disrupted by unwanted pathogens that travel from the brain to the gut. Other factors that can affect the gut-brain axis include:

Sedentary lifestyle
Unhealthy diet
Physical inactivity
Stress
Inflammation
Chronic pain

Visceral Pain

Research shows that visceral pain is described as pain originating from the internal organs of the body and can cause the development of neurological behavioral disorders. Visceral pain can also cause gastrointestinal disorders as it causes damage to the thorax and abdomen while also making maladaptive changes to alter the brain structure and function. Other research studies have found that visceral pain is a complex and heterogeneous disorder that involves the spinal cord, a higher order of the brain structure, and manipulates the gut microbiota. Some of the mechanical features that visceral pain causes gastrointestinal pain and discomfort that can cause painful stimuli to the brain.

Stress

Stress can be both beneficial and harmful to the body, especially to the gut and the brain. When stress is in its acute form, it can help give the body a “fight or flight response” effect that gives the body a little boost of energy. However, when stress is in its chronic state can cause damage to the brain and gut as it can become harmful over time if it is not treated. Studies show that the importance of the gut-brain axis in regulating stress responses has been long appreciated as it can impact mental and gut health. When stress starts to affect both the gut and the brain, the neuron signals will get disrupted and can kill the neuron’s signals and replaced them with new ones to cause havoc on the gut-brain axis. Other studies have found that when a person is under chronic stress, gut infections and inflammation can cause an increase in high-co-morbidity of anxiety and depression disorders in people.

Inflammation

Just like stress, inflammation can be both beneficial and harmful to the body and the brain-gut connection. The beneficial factor of inflammation in its acute form is that it can naturally heal an injury by making the affected area swell up, red, and hot to the touch which can last for a few minutes to an hour, depending on the injury. Studies have shown that the gut-brain connection has molecular and cellular mechanisms that regulate inflammatory responses to the body. However, just like chronic stress, when the body has chronic inflammation can cause havoc on the gut by attaching itself to the intestinal permeability and causing the immune system to attack the permeability causing a leaky gut. For the brain, inflammation can attach to the neuron signals and travel up to the brain to cause havoc on the blood-brain barrier and develop neuroinflammation.

Conclusion

All in all, the gut-brain connection has a wonderful bidirectional connection that makes sure that not only the body is staying functional, but also for each of the organs to do their jobs properly as well. When unwanted pathogens start to affect the brain-gut connection, it can cause numerous problems to the body with chronic inflammation, chronic stress, and many other issues that can cause a person to be in pain. Utilizing a healthy diet filled with nutritional food, getting up to do some sort of physical exercise, and making small changes to a lifestyle habit can dampen the effects of chronic issues that are affecting the body and provide the individual with a pain-free lifestyle.

References

Agirman, Gullistan, et al. “Signaling Inflammation across the Gut-Brain Axis.” Science (New York, N.Y.), U.S. National Library of Medicine, 25 Nov. 2021, pubmed.ncbi.nlm.nih.gov/34822299/.

Appleton, Jeremy. “The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.” Integrative Medicine (Encinitas, Calif.), InnoVision Health Media Inc., Aug. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6469458/.

Bear, Tracey, et al. “The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress.” Microorganisms, MDPI, 31 Mar. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8065970/.

Foster, Jane A, et al. “Stress & the Gut-Brain Axis: Regulation by the Microbiome.” Neurobiology of Stress, U.S. National Library of Medicine, 19 Mar. 2017, pubmed.ncbi.nlm.nih.gov/29276734/.

Medical Professionals, Cleveland Clinic. “Gut-Brain Connection: What It Is, Behavioral Treatments.” Cleveland Clinic, 3 Dec. 2020, my.clevelandclinic.org/health/treatments/16358-gut-brain-connection.

Moloney, Rachel D, et al. “Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome.” CNS Neuroscience & Therapeutics, John Wiley and Sons Inc., Feb. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC6492884/.

Pusceddu, Matteo M, and Melanie G Gareau. “Visceral Pain: Gut Microbiota, a New Hope? – Journal of Biomedical Science.” BioMed Central, BioMed Central, 11 Oct. 2018, jbiomedsci.biomedcentral.com/articles/10.1186/s12929-018-0476-7.

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A Focused Look On The Gut-Brain Axis | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

The gut system makes sure that the good bacteria is helping the gut by digesting the consumed food into nutrients for the body and keeping the unwanted pathogens from causing chronic inflammation to the intestinal permeability barrier. The gut has a pretty good bidirectional connection to the brain as they send signals back and forth to each other while making sure that the body is functional and that everything is working properly. In this 2 part series, we will be taking at what is the gut-brain axis and how does it function in the body. Part 2 will be taking at the different factors that can affect the gut-brain axis. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Is The Gut-Brain Axis?

Also known as the “gut feeling” in the body, the gut-brain axis as research shows that the gut-brain axis has consisted of bidirectional communication between the central and enteric nervous system. The brain sends signals to the gut to make sure that everything is working properly and vice versa. Other studies have also shown that gut microbes actually communicate to the central nervous system through at least 3 parallel interactive channels that include the nervous, endocrine, and immune signaling mechanisms that make the body functional. When the gut or the brain is being dysfunctional, it can cause many problems in the body and can be developed into chronic issues that will happen over time.

The “Forgotten Organ”

Research studies have shown that the intestinal microflora is a positive health asset as it is crucially influenced by the normal structural and fundamental development of the mucosal immune system. What this means is that the bacteria density increases in the jejunum/ileum from the stomach and duodenum. In the large intestine, there are colon-residing bacteria that achieve the highest cell densities recorded for any ecosystem, whether it is the gut or the brain. Other studies have shown that the resident microorganisms in the body establish in their respective colonies while performing a variety of vital functions in the body by exerting a range of protective, structural, and metabolic effects on the intestinal mucosa.

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) are a form of regenerative medicine that both international and nationally affiliated clinics and distribution organizations use to help boost the body’s own natural healing process. HCTP has beneficial properties by repairing cells, diseased organs, and tissues back to their original state and function in the body. With more and upcoming research about the beneficial properties of HCTP, many individuals with either neurological disorders or gut issues can be provided with relief.

Diversity Is The Key For Gut Health

Having diversity in the body is important for gut health as it helps shape a person in the world. The alpha diversity is a measure of the compositional complexity of a community within a site as it increases with the number of present species and with the evenness of their relative abundances in the gut. While the beta diversity looks at the differences in the taxonomic abundance profiles from different samples as presence-absence data are often used to identify which species are shared by samples and which are not. Research studies have shown that the abundance of specific bacterial genera can be significantly predicted by a person’s personality traits. The gut needs bacteria to thrive on the inside as it helps protect the gut from toxins and pathogens that are trying to disturb the microbiota. Other studies have found that when nutritional foods enter the GI microbial ecosystem, it provides macro-and micro-nutrients to the gut microbial as it helps the gut to be diverse, stable, and healthy.

Neurodevelopment & The Gut

Studies have found that the bidirectional communication between the gut and brain is established due to the colonization patterns and cognition at the early stages of a person’s life. The brain is part of the central nervous system that makes sure that the information from the gut is being transferred back to the brain. Other studies have been shown that the production of metabolites can help influence the central nervous system and enhanced the integrity of the intestinal epithelial layer through SCFAs (short-chain fatty acids). The SCFAs traveling back and forth through the gut and the brain allows the bacterial strains will decrease the permeability of the blood-brain barrier.

Microbiota Regulates Anxiety

The gut microbiota actually helps to regulate the body and brain function in the body as it can help monitor the neuron signals that are providing the sensations and emotional signals in the body. Studies have found that when the intestinal flora modulates the gut-brain axis communication, it involves the nervous system, immune system, and endocrine system to make it functional. When the intestinal flora is being affected by pathogens though, it can cause a series of changes in the physical and mental symptoms to occur like anxiety. This is due to any inflammation and dysbiosis that has been affecting the gut, as research studies show that any chronic inflammation has been linked to mental illnesses like anxiety and depression. When a person has inflammation in the gut, it can cause them pain and suffering as they don’t really know what is going on. By establishing antioxidant-riched foods into the gut system, the inflammation can be dampened and even improve brain health.

Conclusion

All in all, the gut-brain axis has a bidirectional connection that makes sure that the gut and the brain are communicating with each other as well as doing their jobs properly. With this bidirectional communication, the gut makes sure that the signaling mechanisms are working properly and that unwanted pathogens are not entering each of the systems. When this happens, both the gut and the brain will begin to be dysfunctional and cause chronic issues to be developed. Utilizing anti-inflammatory foods and exercises can dampen these effects and the individual can begin their life pain-free.

References

Carabotti, Marilia, et al. “The Gut-Brain Axis: Interactions between Enteric Microbiota, Central and Enteric Nervous Systems.” Annals of Gastroenterology, Hellenic Society of Gastroenterology, 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/.

Clapp, Megan, et al. “Gut Microbiota’s Effect on Mental Health: The Gut-Brain Axis.” Clinics and Practice, PAGEPress Scientific Publications, Pavia, Italy, 15 Sept. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/.

Heiman, Mark L, and Frank L Greenway. “A Healthy Gastrointestinal Microbiome Is Dependent on Dietary Diversity.” Molecular Metabolism, Elsevier, 5 Mar. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4837298/.

Johnson, Katerina V-A. “Gut Microbiome Composition and Diversity Are Related to Human Personality Traits.” Human Microbiome Journal, Elsevier Ltd, Mar. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC8336012/.

Martin, Clair R, et al. “The Brain-Gut-Microbiome Axis.” Cellular and Molecular Gastroenterology and Hepatology, Elsevier, 12 Apr. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6047317/.

O’Hara, Ann M, and Fergus Shanahan. “The Gut Flora as a Forgotten Organ.” EMBO Reports, U.S. National Library of Medicine, July 2006, www.ncbi.nlm.nih.gov/pmc/articles/PMC1500832/.

Rothenberg, Sarah E, et al. “Neurodevelopment Correlates with Gut Microbiota in a Cross-Sectional Analysis of Children at 3 Years of Age in Rural China.” Scientific Reports, Nature Publishing Group UK, 1 Apr. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8016964/.

Seo, Dong-Oh, and David M Holtzman. “Gut Microbiota: From the Forgotten Organ to a Potential Key Player in the Pathology of Alzheimer’s Disease.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, Oxford University Press, 18 June 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7302187/.

Warner, Barbara B. “The Contribution of the Gut Microbiome to Neurodevelopment and Neuropsychiatric Disorders.” Pediatric Research, U.S. National Library of Medicine, 25 Sept. 2018, pubmed.ncbi.nlm.nih.gov/30283047/.

Yang, Beibei, et al. “Effects of Regulating Intestinal Microbiota on Anxiety Symptoms: A Systematic Review.” General Psychiatry, BMJ Publishing Group, 17 May 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6551444/.

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An Overview Of Beneficial Ways To Improve GI | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

The gut system’s main function is to digest food to be turned into nutrients in the body and excrete the waste out of the body. The gastrointestinal tract or GI tract makes sure that the beneficial bacteria are keeping the gut happy and healthy while the intestinal permeability is keeping the toxins and unwanted pathogens out. However, when pathogens do enter the gut can start to disrupt the intestinal wall permeability, it can cause gut inflammation and other chronic illnesses to pop up over the gut and cause a person to be in pain. In this 2 part series, we will be taking a look at ways to keep a healthy gut intact. In Part 1, we took a look at what is the GI tract and its role on the gut. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

The Roles Of GI Microbiota

Since the gut system is home to the GI tract, research studies have shown that the GI microbiota plays a role in the body’s physiology, metabolism, and nutrition. The gut makes sure that the body is getting the right amount of nutrients while producing beneficial gut flora to keep everything working. Other research studies have found that gut microbiota has been associated with gastrointestinal diseases like IBD (inflammatory bowel disease), SIBO, metabolic disorders, and neurological disorders just to name a few. The gut is connected to the entire body as it plays a functional role in a person’s health as it is one of the main sources where inflammation seems to target the most.

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) have been used in both international and nationally affiliated clinics and distribution organizations as a form of regenerative therapy treatment. HCTP helps the body boost its own natural healing process by regenerating and repairing damaged cells, diseased tissues, and organs back to their original functioning state. With more and upcoming research discussing the beneficial properties of HCTP, many individuals will begin to feel better from any chronic illnesses that they have encountered and start on their wellness journey.

Ways To Improve GI Microbiota

There are many ways to help improve the GI microbiota in the body. Many individuals will often find ways to improve their lifestyles by making small changes in their daily routines, changing their eating habits, exercising more, and moving around to make their lives better. Research studies have shown that in the gut microbiota the bacteria, fungi, and viruses actually live in a harmonic dynamic equilibrium together in the intestinal tract. The gut needs them in order for the microbiome to thrive and produce good bacteria in order for the gut system to be functional. Other research studies have found that when there is a right balance of microorganisms in the gut, the microbion will improve the body’s mental and physical health as well as other microbiomes.

Stop Taking Antibiotic

Even though antibiotics are beneficial to the body by getting rid of viruses and bacteria, they can cause harm to the gut microbiota. Research studies have shown that when individuals use antibiotics in their system will cause negative effects on their gut microbiota. What antibiotics do to the gut is that they can reduce the bacterial species diversity, cause an altered metabolic activity, and caused a recurrence of viral infections to the gut. Other studies have found that antibiotics can cause microbial dysbiosis and cause the disruption of the gut microbiota. When individuals are taking an excessive amount of antibiotics for chronic illnesses, it can destroy the gut flora and cause even more illnesses to rise, but taking antibiotics in small amounts will get rid of the virus and not harm the GI microbiota.

Berberine

Research studies have shown that when individuals that are suffering from obesity and diabetes due to gut microbial dysbiosis should use berberine. Berberine has been used to dampen the effects of inflammation and lower glucose levels in the body. Other studies have found that berberine has antioxidants and anti-inflammatory properties that can help not only the gut but also provide neuro-protective and cardiovascular-protective effects on the brain and heart.

Probiotics

Known as “living microorganisms”, probiotics are beneficial to the gut as they help get rid of the bad bacteria and feed the good bacteria of the gut. Studies have shown that probiotics contain Lactobacilli, which can help manipulate the intestinal microbial, suppress the pathogens that harm the gut, and stimulate the epithelial cells while fortifying the intestinal barrier. Probiotics are essential to gut health as they are part of the 5R program, which helps reset the gut and helps dampen the effects of inflammation. Other research studies show that the primary job that probiotics provide is that they provide a healthy balance to the body when the bad bacteria start to increase. Probiotics will fight them off and restore balance to the gut and the body.

Conclusion

All in all, finding ways to make sure that the gut stays healthy is by making small changes in the way a person eats, their lifestyles, and exercising can not only help the gut stay healthy but the body as well. When there is inflammation in the gut, it can cause a person to feel bad and if it is not treated right away can develop into chronic inflammation over time. By taking probiotics, eliminating foods that may cause a person inflammation, and eating antioxidant-rich foods can dampen the effects of inflammation to the gut and restore the GI microbiota.

References

Gagliardi, Antonella, et al. “Rebuilding the Gut Microbiota Ecosystem.” International Journal of Environmental Research and Public Health, MDPI, 7 Aug. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6121872/.

Guinane, Caitriona M, and Paul D Cotter. “Role of the Gut Microbiota in Health and Chronic Gastrointestinal Disease: Understanding a Hidden Metabolic Organ.” Therapeutic Advances in Gastroenterology, SAGE Publications, July 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3667473.

Hemarajata, Peera, and James Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology, SAGE Publications, Jan. 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3539293/.

Jandhyala, Sai Manasa, et al. “Role of the Normal Gut Microbiota.” World Journal of Gastroenterology, Baishideng Publishing Group Inc, 7 Aug. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4528021/.

Leonard, Jayne. “10 Research-Backed Ways to Improve Gut Health.” Medical News Today, MediLexicon International, 28 May 2019, www.medicalnewstoday.com/articles/325293.

Medical Professionals, Cleveland Clinic. “Probiotics: What Is It, Benefits, Side Effects, Food & Types.” Cleveland Clinic, 9 Mar. 2020, my.clevelandclinic.org/health/articles/14598-probiotics.

Ramirez, Jaime, et al. “Antibiotics as Major Disruptors of Gut Microbiota.” Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A., 24 Nov. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7732679/.

Zhang, Lichao, et al. “Effects of Berberine on the Gastrointestinal Microbiota.” Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A., 19 Feb. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7933196.

Zhang, Sheng, and De-Chang Chen. “Facing a New Challenge: The Adverse Effects of Antibiotics on Gut Microbiota and Host Immunity.” Chinese Medical Journal, Wolters Kluwer Health, 20 May 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6511407/.

Zhang, Yifei, et al. “Gut Microbiome-Related Effects of Berberine and Probiotics on Type 2 Diabetes (the Premote Study).” Nature News, Nature Publishing Group, 6 Oct. 2020, www.nature.com/articles/s41467-020-18414-8.

Disclaimer

An Insightful Overview Of The GI | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

The gut is home to many bacterias that help out the body by digesting the food that a person eats, and excretes the waste out of the body. The gut system also makes sure that each of the organs is doing its job and sending the information to the brain that everything is working properly. When there are unwanted pathogens that enter the body and start to mess with the gut and the GI tract, it can cause chronic inflammation and unwanted gastrointestinal problems that can disrupt the permeability of the gut. In this 2 part series, we will be taking a look at what is the GI tract and its role in the gut. In Part 2, we will discuss what are ways to keep a healthy gut intact. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Is The GI Tract Function?

In the gut system, the gastrointestinal (GI) tract is part of that system along with the pancreas, the liver, the stomach, the small and large intestines, the mouth, the rectum, and the anus. Research studies have shown that the primary function of the GI tract is to digest and absorb the ingested nutrients and to exert waste products out. When a person eats nutritional food that is insoluble and can’t be digested, the GI tract can turn these insoluble nutrients into soluble nutrients that can permit the body to absorb them in the mucosal epithelium of the gut. Other studies have also shown that when the digestive system breaks down proteins, fats, and carbohydrates, the body can absorb these nutrients and even used them for energy, growth, and cell repair for the body.

Digestion and Absorption

The digestion and absorption from the GI tract help break down complex foods into basic constituents by dividing the macronutrients into basic units and releasing the micronutrients from the food matrix. The GI tract lets the body selectively absorb the nutrients while also transforming them and the phytonutrients while maintaining a barrier against the entry of unwanted particles that enter the body. When there are nutrients that are not absorbed uniformly, there are specific locations where the available transporters or necessary processes are found in the body. Research shows that digestion is highly important for the body because it needs the nutrients from the food and liquids that a person eats and drinks in order to stay healthy. Not only that but the appropriate timing and sequence is also
important as the bowel transit time can adversely affect the GI tract.

When the transporters and enzyme capacity in the body becomes overwhelmed, it can reduce the effective benefits of dietary nutrients for the body to function properly and causes the GI tract to developed unwanted gut disorders. Another factor to take into consideration is that the nutrients can also be produced by colonic bacteria and may have a limited bioavailability that may be beneficial to colonocytes and microbes in the gut system.

Enteroendocrine Cells

The enteroendocrine cells, as studies have found, are the first level of integrating information from the gut lumen and releasing signaling molecules that activate the nerve fibers in the body. The enteroendocrine cells are part of the gut system and the endocrine system that helps release hormones into the bloodstream and travel all throughout the body. Research studies have found that as part of “the largest endocrine organ” or the gut, the enteroendocrine cells play an important role in the lower GI tract as it acts as sensors to the luminal contents by exerting waste out the GI tract like gastric emptying.

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) are part of regenerative therapy treatments that both international and nationally affiliated clinics and distribution organizations use to help individuals dampen the effects of chronic disorders and help boost the body’s own natural healing process. HCTP has beneficial properties that help repair and regenerate damaged cells, tissues, and organs back to their original functional state in the body. As more upcoming research discusses the beneficial properties of HCTP, many individuals can begin their wellness journey pain-free and without chronic pain.

Is It Interface Or Barrier In The Gut?

The permeability and barrier function of the gut is represented as one of the most important interfaces between a person and the external environment. However, by not imagining that the barrier function as a system to keep things out from causing gut problems, but as a sophisticated system that communicates with and allows selectively entry of, certain contents from the gut lumen into the body. The gut barrier requires a tightly controlled but thin barrier of tissues and secretions intentionally designed for close proximity to the gut lumen. This will permit the absorption of available nutrients and physiological interaction with trillions of non-human microbes and their metabolites and signals, but also creates a vulnerability to those same microbes, toxins, and immunologically reactive components from the gut lumen.

Tight Junction

Research studies have found that the tight junction in the gut forms a continuous intercellular barrier that is between the epithelial cells. Since many proteins are actually localized in the tight junction, they become critical barrier proteins that make sure that no toxins or unwanted pathogens leaked out. When inflammation starts to attach itself to the tight junction barrier, the immune system will attack the tight junction and release the toxins and molecules out of the gut permeability causing a leaky gut.

Paneth Cells

Paneth cells are found only in the small intestines and help migrate into the crypt after the differentiation of HCTP and are long-lived compared to absorptive cells. Research has found that paneth cells play an integral role in maintaining intestinal homeostasis and modulating the physiology of the small intestine. The paneth cells actually secrete antimicrobial peptides (AMPs) and immunomodulating proteins into the gut lumen while also providing the function of regulating HCTP activity to help repair the intestinal epithelial cells from injury and intestinal inflammation.

Conclusion

All in all, the gut system is home to the gastrointestinal tract which makes sure that any food or liquids that are consumed are being digested for the nutrients for the body and excrete the waste out. When there are disruptors or pathogens that enter the gut and cause inflammation to the intestinal permeability can cause many gut issues that can cause a person pain. The only way to dampen the effects of inflammation is through neutraceuticals that can lower the inflammatory cytokines and consuming food that contains pre and probiotics to help with producing the good bacteria in the gut. When individuals find ways to lower gut inflammation, then they can continue to be pain-free from inflammation.

References

Anderson, James M, and Christina M Van Itallie. “Physiology and Function of the Tight Junction.” Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, Aug. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2742087/.

Gunawardene, Ashok R, et al. “Classification and Functions of Enteroendocrine Cells of the Lower Gastrointestinal Tract.” International Journal of Experimental Pathology, Blackwell Publishing Ltd, Aug. 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3144510/.

Hornbuckle, William E., et al. “Gastrointestinal Function.” Clinical Biochemistry of Domestic Animals, U.S. National Library of Medicine, 22 Oct. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC7173558.

Lueschow, Shiloh R, and Steven J McElroy. “The Paneth Cell: The Curator and Defender of the Immature Small Intestine.” Frontiers in Immunology, Frontiers Media S.A., 3 Apr. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7145889/.

Medical Professionals, Cleveland Clinic. “Digestive System: Function, Organs & Anatomy.” Cleveland Clinic, 9 Aug. 2021, my.clevelandclinic.org/health/body/7041-digestive-system.

Medical Professionals, NIDDK. “Your Digestive System & How It Works.” National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health and Human Services, Dec. 2017, www.niddk.nih.gov/health-information/digestive-diseases/digestive-system-how-it-works.

Sternini, Catia, et al. “Enteroendocrine Cells: A Site of ‘Taste’ in Gastrointestinal Chemosensing.” Current Opinion in Endocrinology, Diabetes, and Obesity, U.S. National Library of Medicine, Feb. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2943060/.

Disclaimer

Spondylitis Anti-Inflammation Diet

Dr. Alex Jimenez

Spondylitis Anti-Inflammation Diet: Individuals who have a chronic back pain condition can be recommended to have two or more vertebrae fused to correct the problem/s and alleviate the pain. However, a form of inflammatory spinal arthritis can cause the vertebrae to fuse by themselves, known as ankylosing spondylitis. One recommended way to bring pain relief is by eating an anti-inflammatory diet. Studies have shown that a low-inflammatory diet can help improve spondylitis symptoms.

Table of Contents

Spondylitis Anti-Inflammation Diet

Ankylosing spondylitis is a progressive inflammatory disease that primarily affects the spine; however, individual symptoms vary. Symptoms include stiffness and pain in the neck, hips, low back, and fatigue. There is no definite pattern meaning:

Symptoms can improve.
Symptoms can worsen or flare up.
Symptoms can stop for a period of time.

Women are affected more often than men with no known cause. There is no cure for ankylosing spondylitis, but treatments and self-care can slow down the disease’s progression and help manage symptoms.

Diet and Inflammation

Diet is not the root cause of inflammatory disease, but eating inflammation-causing foods can worsen symptoms. Reducing inflammation can help alleviate pain.

Eliminating foods that cause or increase inflammation is recommended to help the body become stronger and manage symptoms.
Another way is to incorporate spondylitis anti-inflammation foods.
Functional medicine practitioners can help guide individuals on maximizing healthy nutrition and using it to reduce pain and symptoms.
If an individual has a genetic predisposition, their diet can be crucial to calm down the symptoms and help turn the autoimmune disease around.

A spondylitis anti-inflammation diet should be rich in vegetables, fruit, whole grains, and omega-3 fatty acids. Evidence shows that a diet low in starches can lead to less ankylosing spondylitis activity. Low-starch can also help limit the presence of Klebsiella pneumoniae, a bacteria that feeds on starch and is a known trigger for the onset and development of ankylosing spondylitis.

Foods To Eat

Leafy greens

These include spinach, kale, Swiss chard, and collard greens containing magnesium and polyphenols that reduce inflammation.
These can be raw or cooked with garlic and olive oil added to maximize benefits.

Cruciferous vegetables

These contain sulforaphane, an antioxidant that includes broccoli cauliflower and can be eaten raw or cooked, roasted with olive oil, sauteed, and stir-fried.

Allium Vegetables

These contain sulfuric compounds and quercetin, a flavonoid that helps reduce inflammation.
These include red and yellow onions, leeks, garlic, and shallots.
They can be eaten raw or cooked in salads, stir-frys, and sandwiches.

Berries

These contain anthocyanin, an antioxidant flavonoid, and other antioxidants and polyphenols that help with inflammation.
These include strawberries, raspberries, blueberries, blackberries and can be eaten raw, in smoothies, in salads, with oatmeal, or mixed in unsweetened yogurt.

Fruits

Certain fruits contain quercetin and polyphenols to help with inflammation.
These include apples, cherries, oranges.

Healthy oils

Contain oleocanthal which acts similar to nonsteroidal anti-inflammatory medications and contains various antioxidants.
These include olive oil for low heat cooking and avocado oil for high heat cooking to replace butter and margarine.
It can be served in dressings and drizzled on foods.

Nuts and seeds

These contain alpha-linolenic acid, which is a type of omega-3 fatty acid.
Examples include walnuts, almonds, peanuts, pistachios, chia seeds, and ground flaxseeds.
These can be served as snacks, salads, mixed in side dishes, topping, or added to unsweetened yogurt or oatmeal.

Fatty fish

Omega-3 fatty acids help reduce inflammation.
Examples include salmon, cod, rainbow trout, mackerel, and sardines.
These can be baked, sauteed, grilled, mixed into salads, and stir fry.

Avoid These Foods

When making lifestyle adjustments for a spondylitis anti-inflammation diet, focus on reducing or removing processed foods and saturated fats. These include:

Sugars from all sources like soda, sugary drinks, shakes, candy, and desserts.
Trans fats, like those in fried foods like chips and fries.
Starches, such as found in potatoes.
Refined carbohydrates, processed grains that include white bread, and pastries.
Red meat.
Gluten.
Dairy.
Eggs.

Individuals may not be symptomatic with certain foods, but that doesn’t mean the foods should be consumed. Gluten, dairy, and eggs can cause potential problems as they compromise the gut and the immune system. These can set back the individual’s healing or remission.

Body Composition

What Happens To The Body When Eating Fruit

Fruit is made up of simple sugar called fructose, providing the body with a carbohydrate energy source. The natural sugar the body gets from a piece of fruit is not the same as processed fructose added to processed products like fructose corn syrup. Processed products are typically filled with empty calories and very little nutrition. When the body has fruit, the liver processes fructose before getting absorbed through the small intestine. Research shows that exposing the gut to more fiber-rich foods like fruit helps the gut achieve an anti-obese condition by increasing the good bacteria and reducing the obese bacteria. Essential nutrients from fruit include:

Folate
Vitamin C
Vitamin B1

The USDA recommends making half of each meal/plate be fruit and vegetables.

References

Harvard Health Publishing. (November 16, 2021) “Foods that Fight Inflammation.” www.health.harvard.edu/staying-healthy/foods-that-fight-inflammation

Macfarlane, Tatiana V et al. “Relationship between diet and ankylosing spondylitis: A systematic review.” European journal of rheumatology vol. 5,1 (2018): 45-52. doi:10.5152/eurjrheum.2017.16103

Nielsen, Forrest H. “Magnesium deficiency and increased inflammation: current perspectives.” Journal of inflammation research vol. 11 25-34. January 18 2018, doi:10.2147/JIR.S136742

Rashid T, Wilson C, Ebringer A. The Link between Ankylosing Spondylitis, Crohn’s Disease, Klebsiella, and Starch Consumption. Clin Dev Immunol. 2013;2013:872632. doi: 10.1155/2013/872632.

Sharma, Satya P et al. “Paradoxical Effects of Fruit on Obesity.” Nutrients vol. 8,10 633. 14 Oct. 2016, doi:10.3390/nu8100633

van Buul, Vincent J et al. “Misconceptions about fructose-containing sugars and their role in the obesity epidemic.” Nutrition research reviews vol. 27,1 (2014): 119-30. doi:10.1017/S0954422414000067

Regenerative HCTP Therapy In Neurodegenerative Disorders

Dr. Alex Jimenez

Table of Contents

Introduction

The brain’s primary function in the central nervous system is to transport and transmit neuron signals all throughout the entire body. These neuron signals help the body, gut, immune, endocrine, and musculoskeletal systems do their jobs properly and send the information back to the brain. When there are disruptors that enter the body and attach to the neuron signals, they can disrupt the signals while traveling to the brain. When this happens, the brain will develop neurodegenerative disorders over time and cause havoc on the body making it dysfunctional. There are many therapeutic ways to dampen the effects of neurodegenerative disorders and one of them is through regenerative HCTP therapy. In this article, we will be taking a look at what is the pathology of neurodegenerative disorders and how regenerative HCTP therapy can affect neurodegenerative disorders. By referring patients to qualified and skilled providers who specialized in neurological services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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What Is Neurodegenerative Disease?

According to WHO global study, 8 out of 10 disorders in the 3 highest disability classes are neurologic problems. Research studies have found that neurodegenerative diseases occur when the brain’s nerve cells start to lose function and die over time. Neurodegenerative diseases can vary from the symptoms that a person is experiencing and can be numerous risk factors as well. All over the world, there are over 276 million people that are disabled due to neurodegenerative diseases since it is a progressive age disease. Other studies have found that neurodegenerative diseases can be frequently observed due to ischemic, metabolic, toxic, infectious, and traumatic insults of the brain. As many people start to live longer, many neurodegenerative diseases will begin to increase over time due to age.

The Pathology of Neurodegenerative Disease

The pathology of neurodegenerative diseases can be many factors that the body has gone through. Some of these factors that can cause neurodegenerative diseases to rise include:

Reactive Oxygen Species (ROS) generation-causing chronic inflammation
Proteasome complex impairment
Mitochondrial function impairment
Toxic protein aggregation
Neurotoxic oligomers
Genetic factors

Studies have found that with the pathology of neurodegenerative diseases is often characterized by a progressive loss of selectively vulnerable population of neurons in the brain. Now, this is different than regular disruptors due to the neuronal loss from metabolic or toxic disorders that a person may already have with their current lifestyle. Other factors that can cause the pathology of neurodegenerative diseases to develop over time are an unhealthy lifestyle like not getting enough exercise, eating nutritional foods, or not moving around a lot can cause the cognitive functions in the brain to shrink slowly and develop into cognitive dysfunction over time.

HCTP Therapy

HCTP (human cellular tissue products) or stem cells* are part of regenerative cellular treatment that both international and nationally affiliated clinics and distribution organizations use to help boost the body’s own natural healing process. HCTP can help individuals by repairing and regenerating damaged cells, diseased tissues, and organs back to their original state and function in the body. As more and upcoming research discusses the beneficial properties of HCTP, many individuals will begin on their wellness journey without being in chronic pain.

HCTP In Neurodegenerative Diseases

As stated earlier, HCTP or human cellular tissue products are used in both international and nationally affiliated clinics and distribution organizations that are specialized in this type of therapeutic treatment for individuals that are suffering from neurodegenerative diseases. Research studies have found that regenerative HCTP therapy has dampened the effects of neurodegenerative diseases from progressing further by regenerating the cellular structure and function of neurons in the brain. Some of the precise mechanisms of HCTP therapy for neurodegenerative diseases are still unknown but the beneficial factors that HCTP can offer include:

Growth factor secretion
Glial cell-derived neurotrophic factor (GDNF)
Vascular endothelial growth factor (VEGF)
Brain-derived neurotrophic factor (BDNF)
Neuroinflammation attenuation
Exosome and miRNA secretion
Mitochondria donation

Other research studies have found that regenerative HCTP therapy has the capability to repair injured neuronal tissues in the brain. HCTP actually provides the existing healthy neurons and glial cells protection from any further damage that can harm the brain.

HCTP & Parkinson’s

Research studies have found that Parkinson’s disease is one of the most insidious neurodegenerative diseases worldwide. However, with the use of regenerative HCTP therapy, many of the damaged neuronal will be able to regenerate. HCTP can help with the secretion of neurotrophic growth factors while also modulating the immune system via direct cell-to-cell interactions and aid wound healing. Other research studies have found that regenerative HCTP can improve neuronal health by mitochondrial donation and affect DAergic neurons via prostaglandin E2 and its signaling pathway by releasing dopamine by depolarizing potassium channels and dampening the effects of Parkinson’s.

HCTP & Stroke

When individuals suffer from a stroke, their entire outlook on life will begin to plummet as they try to piece themselves back together. Research studies have found that since inflammation is part of a major pathological event that follows an ischemic stroke, regenerative HCTP therapy can help dampen the effects of chronic neuroinflammation to the brain. When inflammation starts to infiltrate into the brain that suffered from a stroke, it can cause a disruption to the blood-brain barrier, which causes the pro-inflammatory cytokines to be released and infiltrate the immune cells. Other research studies show that the ischemic tissues can help enhanced HCTP recruitment from peripheral blood and are associated with enhanced neurogenesis, angiogenesis, and synaptogenesis. Other beneficial results that HCTP can provide to minimized the effects of a stroke are:

Inflammation attenuating
Attenuated neuronal death by suppressing activated microglia
Scar thickness reduction
Autophagy enhancing
Microenvironmental/metabolic profiles normalization

Conclusion

All in all, with many more research studies about the beneficial uses of HCTP, there are still ways to help dampen the effects of neurodegenerative diseases that many individuals can do. Either eating the right amount of foods that are filled with vitamins and minerals can help dampen inflammation in the body or exercising both mentally and physically can improve cognitive function by making the brain work on remembering what the person is doing can help the brain stay healthy and young. When neurodegenerative diseases start to affect the brain, it can cause symptoms of dementia, Alzheimer’s, or Parkinson’s’ to worsen over time. By incorporating therapeutic treatments like regenerative HCTP therapy into a person’s wellness journey can be beneficial to the individual.

References

Chang, Ying-Chao, et al. “Regenerative Therapy for Stroke.” Cell Transplantation, U.S. National Library of Medicine, 2007, pubmed.ncbi.nlm.nih.gov/17474298/.

Dugger, Brittany N, and Dennis W Dickson. “Pathology of Neurodegenerative Diseases.” Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 5 July 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5495060/.

Díaz, Mariacruz L. “Regenerative Medicine: Could Parkinson’s Be the First Neurodegenerative Disease to Be Cured?” Future Science OA, Future Science Ltd, 10 Oct. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6787491/.

Professionals, NIEHS. “Neurodegenerative Diseases.” National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services, 11 Feb. 2022, www.niehs.nih.gov/research/supported/health/neurodegenerative/index.cfm.

Przedborski, Serge, et al. “Neurodegeneration: What Is It and Where Are We?” The Journal of Clinical Investigation, American Society for Clinical Investigation, Jan. 2003, www.ncbi.nlm.nih.gov/pmc/articles/PMC151843/.

Rajkovic, Olivera, et al. “Regenerative Medicine Therapies for Targeting Neuroinflammation After Stroke.” Frontiers in Neurology, Frontiers Media S.A., 3 Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6129611.

Sakthiswary, Rajalingham, and Azman Ali Raymond. “Stem Cell Therapy in Neurodegenerative Diseases: From Principles to Practice.” Neural Regeneration Research, Medknow Publications & Media Pvt Ltd, 15 Aug. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC4302533/.

Sivandzade, Farzane, and Luca Cucullo. “Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview.” International Journal of Molecular Sciences, U.S. National Library of Medicine, 22 Feb. 2021, pubmed.ncbi.nlm.nih.gov/33671500/.

Yasuhara, Takao, et al. “Regenerative Medicine for Parkinson’s Disease.” Neurologia Medico-Chirurgica, The Japan Neurosurgical Society, 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4533405.

Disclaimer

Peptides For Neurodegenerative Disorders

Dr. Alex Jimenez

Table of Contents

Introduction

The central nervous system’s main function is to make sure that the neuron signals are being transmitted all over the entire body. These neuron signals make sure that not only the body is functioning properly but the gut, the immune system, the endocrine system, and even the brain itself are doing their jobs. These neuron signals must have a bidirectional connection with the brain in order to make the body move, feel and sense things throughout a person’s day. When there are unwanted pathogens that enter the body and attach themselves to the neuron signals, they can travel to the brain and cause neurodegenerative diseases to develop over time if they are not treated. Luckily there are some therapeutic options like peptide therapy to help dampen the effects of neurological diseases in the brain. In this article, we will be taking a look at what are peptides, how they affect neurodegenerative diseases, and how they help the brain. By referring patients to qualified and skilled providers who specialized in neurological services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Are Peptides?

In the body, there are molecules and antibodies that make sure that the body is functioning properly. Research studies have shown that peptides represent a unique class of pharmaceuticals compounds that are the foundation of all cellular processes. Peptides have been on the “fringes” of medicine until recently. In the past, they had a few problems that made them unaffordable due to their high cost, limited availability, and their short half-lives. However, that changed as peptides became more Pharma driven, have improved the bioavailability, and have recombinant technology and genetic engineering. Other studies have shown that peptides have been receiving increased interest since they possess favorable tissue penetration and the capability to engage with endogenous receptors in the body. What this means is that peptides can be versatile tools to help release the active components from food protein sources and provide the body health benefits that it needs.

Peptides For Neurological Disorders

Since neurological disorders are selective and progressive in the brain, research studies have found that peptides can provide therapeutic mechanisms that may be effective in dampening the symptoms and slowing down the onset progression of neurodegenerative disorders. Other beneficial factors that peptides can provide to the body include:

Growth hormone supportive
Neuroprotective/Neuroregenerative
Decreases microglial inflammation
GUT‐BRAIN axis support
Immune supportive

Other research studies have shown that since peptides are small molecules that are composed of amino acids that are linked to peptide bonds, they have the ability to reach different locations in the body that are complicated to access and provide treatment to neurological disorders.

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) are a form of regenerative medicine that helps boost the body’s own natural healing process. Both international and nationally affiliated clinics and distribution organizations use HCTP to help repair and regenerate damaged cells, tissues, and organs back to their original state and function in the body. With more and upcoming research that informs individuals about the benefits of HCTP, many individuals can become pain-free and continue on their wellness journey.

GH & The Brain

GH receptor and GH (growth hormone) themselves are expressed widely in the brain and studies have shown that growth hormone replacement therapy can affect the cerebrospinal fluid levels for various hormones and neurotransmitters but also provide beneficial effects for cognitive function in the brain. Growth hormones have been reported to alter:

Neurogenesis
Myelin synthesis
Dendritic branching
Neural HCTP cells which are activated by GH

Growth hormones have also occurred in the hippocampus in response to a memory task since the cognitive domains are grouping them as either “crystallized” or “fluid” intelligence (short-termed or long-termed memory. Other studies have found that growth hormones can help with the development and function of the brain since growth hormones help with activating neural HCTP cells and downstream IGF‐1, IGF‐2. Several studies have shown a correlation between plasma IGF‐I concentrations and performance on tests of fluid intelligence, suggesting that GH may play a role in the maintenance of fluid intelligence.

IGF-1

Insulin‐like growth factor 1 (IGF1) is a polypeptide hormone that is structurally similar to insulin. It is central to the somatotropic axis, acting downstream of growth hormone (GH), and activates both the mitogen‐activated protein (MAP) kinase and PI3K signaling pathways. IGF-1 acts in almost every
tissue in the body to promote tissue growth and maturation through upregulation of anabolic processes. Studies have shown that IGF-1 is secreted by the liver and is transported to other tissues in the body while acting as an endocrine hormone. Since IGF1 expression levels decrease again later in life, low‐dose IGF1 treatment triggered a small increase in the differentiation of neuronal progenitors into neurons. While other studies have found that IGF1 signaling is key in promoting organized adult hippocampal neurogenesis due to the neurotrophic effects of IGF1 signaling, giving evidence for promotion of neurogenesis, development and maturation, myelination, prolonged survival, and resistance to injury, and the levels do decrease later in life.

Thymosin Alpha 1

Research shows that Thymosin Alpha 1 is a synthetic thymic peptide that naturally occurs in the thymus, while also being recognized to modify, enhance, and restore immune function in the body. Thymosin Alpha 1 contains 28 amino acids while promoting T cell differentiation and maturation in vivo and in vitro data while balancing the Th1/Th2 responses in the body. Other research studies have found that since the immune system plays an essential role in brain development, Thymosin Alpha 1 helps with neuronal plasticity and behavioral function as well as inhibiting viral replication as an antioxidant. This peptide also enhances dendritic cells and antibody responses while blocking steroid‐induced apoptosis of thymocytes with its anti-tumor effects plus providing protection against oxidative damage to the brain.

Conclusion

All in all, peptides are highly important for brain development and function as the central nervous system is responsible for transmitting neuron signals all throughout the entire body. When there are unwanted pathogens that start to attach themselves to the neuron signals, they can travel up to the brain and cause neurodegenerative disorders to the brain. Utilizing therapeutic treatments to help dampen the effects of neurodegenerative disorders and maintain the brain’s cognitive function, can help individuals continue on their wellness journey and be pain-free.

References

Dominari, Asimina, et al. “Thymosin Alpha 1: A Comprehensive Review of the Literature.” World Journal of Virology, Baishideng Publishing Group Inc, 15 Dec. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7747025/.

F;, Nyberg. “Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance.” Frontiers in Neuroendocrinology, U.S. National Library of Medicine, Oct. 2000, pubmed.ncbi.nlm.nih.gov/11013068/.

Laron, Z. “Insulin-like Growth Factor 1 (IGF-1): A Growth Hormone.” Molecular Pathology : MP, British Medical Journal Publishing Group, Oct. 2001, www.ncbi.nlm.nih.gov/pmc/articles/PMC1187088/.

Lee, Andy Chi-Lung, et al. “A Comprehensive Review on Current Advances in Peptide Drug Development and Design.” International Journal of Molecular Sciences, MDPI, 14 May 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6566176/.

Martínez-Villaluenga, Cristina, and Blanca Hernández-Ledesma. “Peptides for Health Benefits 2019.” International Journal of Molecular Sciences, MDPI, 6 Apr. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7178072/.

Tiwari, Shashi Kant, and Rajnish K Chaturvedi. “Peptide Therapeutics in Neurodegenerative Disorders.” Current Medicinal Chemistry, U.S. National Library of Medicine, 2014, pubmed.ncbi.nlm.nih.gov/24533803/.

Wrigley, Sarah, et al. “Insulin-like Growth Factor 1: At the Crossroads of Brain Development and Aging.” Frontiers in Cellular Neuroscience, Frontiers Media S.A., 1 Feb. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5285390/.

Yadav, Asmita, et al. “Peptide-Based Therapy for Neurological Disorders.” Current Protein & Peptide Science, U.S. National Library of Medicine, 27 Dec. 2021, pubmed.ncbi.nlm.nih.gov/34544337/.

Disclaimer

Elderly Sciatica

Dr. Alex Jimenez

Pain in Lower Back. Sciatica Nerve Pain. — Sciatica nerve pain. Senior Woman with Pain in Lower Back.

As individual bodies age, the nerves and muscles begin to degenerate, especially in the lower spinal region. This can cause sciatic pain and muscle weakness. Elderly sciatica is very common as the nerves and muscles have gone through a lot. Bending, lifting, carrying, reaching, twisting, and natural wearing and tearing make the sciatic nerve and surrounding muscles prone to injury. For overweight seniors, the risk of developing sciatica is higher.

Table of Contents

Elderly Sciatica

The main reason for elderly sciatica is that as the body ages, the discs/cartilage between the vertebrae/bones in the spine dry out, losing their cushioning ability, which can lead to the bones shifting out of place more easily, rubbing against each other, and compressing nerves. On average, the body loses about 1 centimeter in height every ten years after 40.

Risk Factors

Diabetes

Diabetes affects the entire body.
Not keeping blood sugar in check can cause widespread symptoms that affect the nerves and organs.
Individuals with diabetes have an increased risk of developing sciatica and other nerve-damaging disorders.

Genetics

If spinal conditions are part of family medical history, there is an increased risk of developing sciatica.
Many spinal disorders can cause sciatica, and many spinal diseases are genetic.
For example, degenerative disc disorder and spinal stenosis are genetic conditions that can cause sciatica.

Controllable Risk Factors

Physical Activity

Sedentary and highly active lifestyles can cause sciatica.
Individuals who are highly sedentary have a greater risk of developing elderly sciatica.
Individuals who are highly active and do heavy lifting are also at risk because the activity increases the risk for a back injury.

Weight

The more overweight an individual is, the more at risk for developing sciatica.
The extra weight pushes on the spine and causes it to compress.
As the spine compresses, it can rub against the nerves causing irritation or pinch the nerves causing numbness, tingling, stinging, and pain.

Menopause

Menopause can lead to bone loss, causing nerve irritation and nerve damage.
If going or have gone through menopause, then it is essential to talk to a doctor about bone loss.
Individuals may need to start taking calcium or vitamin D supplements to keep their bones healthy.

Chiropractic

With chiropractic, elderly individuals can attain better quality sleep, improved mood, and increased energy levels.
A chiropractic physical therapy team can develop a specialized/customized treatment plan for preventive and palliative care.

Body Composition

Sarcopenia

Sarcopenia affects the elderly population’s mortality, cognitive function, and quality of life. As the elderly population is living longer, preservation of lean mass becomes an integral part of maintaining an individual’s independence. Loss of muscle in the arms and legs is linked to decreased mobility, increased risk of falls, and prolonged hospital stays. Falls and fractures often result in a cycle of muscle deterioration. InBody can help track body composition changes and help to minimize muscle wasting and risk of impaired mobility.

References

Aggarwal, Sameer, and Nityanand. “Calcium and vitamin D in postmenopausal women.” Indian journal of endocrinology and metabolism vol. 17,Suppl 3 (2013): S618-20. doi:10.4103/2230-8210.123549

Dougherty, Paul E et al. “The role of chiropractic care in older adults.” Chiropractic & manual therapies vol. 20,1 3. 21 Feb. 2012, doi:10.1186/2045-709X-20-3

Ferreira, Manuela L, and Andrew McLachlan. “The Challenges of Treating Sciatica Pain in Older Adults.” Drugs & aging vol. 33,11 (2016): 779-785. doi:10.1007/s40266-016-0404-z

Kherad, Mehrsa et al. “Risk factors for low back pain and sciatica in elderly men-the MrOS Sweden study.” Age and aging vol. 46,1 (2017): 64-71. doi:10.1093/ageing/afw152

Light Therapy For Brain Disease | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

The brain is part of the central nervous system and its primary function is to transmit neuron signals all throughout the entire body. The neuron signals make sure that not only the body is functioning, but that the heart is beating regularly, the gut is digesting the food, blood pressure and the feeling sensations are normal. When there are unwanted pathogens that attach themselves to the neuron signals and travel to the brain, can develop into neurodegenerative diseases over time. Luckily there are therapeutic ways to dampen the effects of neurodegenerative diseases and one of them is low laser light therapy. In this 2 part series, we will be taking a look at how light therapy can be beneficial for individuals that are suffering from neurodegenerative diseases. Part 1 took a look at how different microbial infections are involved in neurodegeneration to the brain. By referring patients to qualified and skilled providers who specialized in neurological services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

Low-Laser Therapy For The Brain

Seeing how neurological and neuropsychiatric diseases are degenerative in nature that are characterized by protein aggregation, there are novel methods to treat protein aggregation and downstream issues since the human body utilizes light energy to catalyze chemical reactions and help dampen the effects of protein aggregation. This is referred to as “photobiomodulation” or low laser therapy. Low laser therapy has endogenous molecules that have different absorption peaks throughout the electromagnetic spectrum, thus resulting in different physiological effects:

Melanin (~340nm)
Unbound hemoglobin (~430nm)
Water (~1900nm)
Reduced mitochondrial Cytochrome C (~605nm)

Studies have found that low laser therapy when applied to the forehead and scalp areas of an individual with traumatic brain injury has helped improve cognitive function in the brain. By altering human physiology with light is a potent therapeutic for numerous conditions as the common “therapeutic range” of laser wavelengths for treating disease is from ~600nm to 1000nm. These wavelengths readily penetrate tissues while hitting disease-relevant biological targets.

The Mechanisms Of LLT

Research studies show that low laser therapy does exert beneficial effects on the motor and histopathological outcomes after traumatic brain injury, while also improving cognitive recovery and limiting the inflammation after the injury. The mechanisms at cellular and molecular levels of low laser therapy can help increase ATP production, release nitric oxide, changes the body’s gene expression while normalizing the membrane potentials via activation of light-sensitive ion channels. Even though a functional brain can change from photobiomodulation, it’s not all about increasing blood circulation. Other beneficial factors that low laser therapy include:

Heat shock protein induction
Angiogenesis and increased blood flow
Reduced pain and inflammation
Increased tissue growth
Increased HCTP proliferation
Reduced tissue atrophy (due to lower apoptosis rate)
Improvement in motor function in skeletal muscle

Other studies have found that the application of low laser therapy on the scalp can help improve mitochondrial function and increase adenosine triphosphate (ATP), which both are important for cellular metabolism. This allows nitric oxide to be released locally and increases the regional cerebral blood flow to the brain.

HCTP Therapy

HCTP (human cellular tissue products) or stem cells* are part of regenerative cellular treatment that both international and nationally affiliated clinics and distribution organizations utilize to help boost the body’s own natural healing process. HCTP is used to repair and regenerate damaged cells, diseased tissues, and organs back to their original functioning state in the body. With more and upcoming research about the beneficial properties of HCTP, many individuals can begin their wellness journey pain-free.

The “Rainbow Effect”

Known as the “Rainbow Effect,” chromotherapy is a method of treatment that uses the color spectrum of electromagnetic radiation to help diseases as studies show. With low laser therapy helping cognitive function, many healthcare professionals use the color light wavelengths to help the body feel less pain. Each of the different electromagnetic wavelengths is correlated to the colors of the rainbow and provides different frequencies to tackle what ailments a person is feeling. Some of the other treatments that chromotherapy and low laser therapy offer include:

Methylene Blue
UV Blood Irradiation
Antimicrobial Photodynamic Therapy

Methylene Blue

Multi-use dye has been historically used for malaria and methemoglobinemia and methylene blue acts as an electron donor for ETC Complex IV. It can absorb light like an endogenous cytochrome oxidase to increase catalysis while also boosting oxygen consumption and ATP output in the body. Research studies have found that methylene blue can cross the blood-brain barrier and form a reversible reduce-oxidation system that has auto-oxidizing capacity. With methylene blue inhibiting recombinant protein aggregation in vitro, even when added to preformed oligomers and fibrils. Other studies have found that methylene blue can help improve memory retention of extinction of fear conditioning in the brain. It can help combat impaired mitochondrial metabolism with its antioxidant effects and increased survival of primary cortical neurons transduced with mutant Htt, reduced neurodegeneration.

UV Blood Irradiation

Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases
including septicemia, pneumonia, tuberculosis, arthritis, asthma, and even poliomyelitis. The early studies were carried out by several physicians in the USA and published in the American Journal of Surgery. However, with the development of antibiotics, UBI use declined and it has now been called “the cure that time forgot”. Research studies have found that UV blood irradiation has been used as an alternative approach to treating infections as an immuno-modulating therapy while also normalizing blood parameters. The amazing results are thought to come from effects on the immune system by:

Increased phagocytosis
Increases secretion of NO and reactive nitrogen species
Deactivation of circulating lymphocytes may reduce inflammation
Transient increase in ROS activates antioxidant defenses

Antimicrobial Photodynamic Therapy

Antimicrophotodynamic therapy is a therapeutic approach that can kill microorganisms by combining light (of a specific wavelength), a light-sensitive substance (photosensitizer), and oxygen effective against drug-resistant pathogens. Studies have found that antimicrobial photodynamic therapy has been used to treat infections that are in the body cavities and is an anon-toxic dye that binds to microbes in the body with few side effects and is cost-efficient.

As studies show that photosensitizers provide bacterial inactivation due to their interaction with oxygen and ROS. Since photosensitizers absorb photons and are excited to a highly reactive state, their reaction with ambient oxygen generates reactive oxygen species and causes irreparable damage to microbe DNA and cell walls to their death.

Conclusion

All in all, it is important to find many therapeutic ways to treat numerous brain disorders and diseases that can cause the brain to be dysfunctional and cause the body to develop chronic illnesses. Since the brain is part of the central nervous system, the neuron signals need that bidirectional connection with the body, the organs, and the brain in order to function. Making small changes in a person’s lifestyle and eating habits can improve cognitive function and allow individuals to be well off in their wellness journey.

References

Azeemi, Samina T Yousuf, and S Mohsin Raza. “A Critical Analysis of Chromotherapy and Its Scientific Evolution.” Evidence-Based Complementary and Alternative Medicine: ECAM, Oxford University Press, Dec. 2005, www.ncbi.nlm.nih.gov/pmc/articles/PMC1297510/.

Hamblin, Michael R, and Tayyaba Hasan. “Photodynamic Therapy: A New Antimicrobial Approach to Infectious Disease?” Photochemical & Photobiological Sciences: Official Journal of the European Photochemistry Association and the European Society for Photobiology, U.S. National Library of Medicine, May 2004, www.ncbi.nlm.nih.gov/pmc/articles/PMC3071049/.

Hamblin, Michael R. “Ultraviolet Irradiation of Blood: ‘The Cure That Time Forgot’?” Advances in Experimental Medicine and Biology, U.S. National Library of Medicine, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6122858/.

Khuman, Jugta, et al. “Low-Level Laser Light Therapy Improves Cognitive Deficits and Inhibits Microglial Activation after Controlled Cortical Impact in Mice.” Journal of Neurotrauma, Mary Ann Liebert, Inc., 20 Jan. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3261787/.

Naeser, Margaret A, et al. “Improved Cognitive Function after Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports.” Photomedicine and Laser Surgery, Mary Ann Liebert, Inc., May 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3104287/.

Naeser, Margaret A, et al. “Significant Improvements in Cognitive Performance Post-Transcranial, Red/near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study.” Journal of Neurotrauma, Mary Ann Liebert, Inc., 1 June 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4043367/.

Pinto, Juliana Guerra, et al. “Efficiency of Antimicrobial Photodynamic Therapy with Photodithazine® on MSSA and MRSA Strains.” Antibiotics (Basel, Switzerland), MDPI, 17 July 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8300773/.

Riha, Penny D, et al. “The Brain Metabolic Enhancer Methylene Blue Improves Discrimination Learning in Rats.” Pharmacology, Biochemistry, and Behavior, U.S. National Library of Medicine, Apr. 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC2040387/.

Rodriguez, Pavel, et al. “Methylene Blue Modulates Functional Connectivity in the Human Brain.” Brain Imaging and Behavior, U.S. National Library of Medicine, June 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5018244/.

Disclaimer

Microbial Involvement In Neurodegeneration | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

The central nervous system is home to the brain and spinal cord as they help send out trillions of neuro signals all throughout the entire body. These neuron signals make sure that the body is moving properly, the gut is digesting the foods that a person is consuming, and that the endocrine system is releasing the hormones out to all of the organs systems. The neuron signals have a bidirectional connection from the brain to the body, however, when there are unwanted pathogens that start to enter the body and attach themselves to the neuron signals, they can travel to the brain and cause neurodegenerative disorders to the brain. In this 2 part series, we will be taking a look at how different microbial infections are involved in neurodegeneration to the brain. In Part 2, we will take a look at how light therapy can be beneficial for individuals that are suffering from neurodegenerative diseases. By referring patients to qualified and skilled providers who specialized in neurological services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

Microbial Involvement In Neurodegeneration

Since there are many individuals that have been exposed to numerous amounts of pathogens that respond to environmental stresses by entry into a novel physiological state as spores or biofilms where the cells remain viable but are no longer culturable. These microorganisms can cause the brain to the development of neurodegeneration. Studies have shown that since neurodegeneration is referring to the loss of neuronal cells, microorganisms that are derived from infections that are involved in chronic inflammation can be induced into central nervous system dysfunction and neurodegeneration. The assessment of whether microorganisms cause a particular disease have to show that:

The microorganism must be found in diseased but not healthy individuals
The microorganism must be cultured from the deceased individual
The microorganism must recapitulate the disease
The microorganism must be re-isolated from the diseased individual and matched to the original microorganism.

However, The issue is that microbial pathogens can lie dormant and resist being positively culture is due to neurodegeneration since it is a re-activation of microbes from this ‘viable but nonculturable’ state to cause infection.

Altered Immunity

Research studies have found that the immune system actually plays a key role in the central nervous system since the immune system is the first line of defense against pathogens that can cause the alternation of the central nervous system to be damaged by the elevated cytokines including IL-6 in early-stage disease. Other studies have shown that when age-related neurological diseases like Alzheimer’s or Parkinson’s can be characterized by the selective vulnerability of the brain regions and the immune responses. In the later stages of age-related neurological diseases, the characteristic findings include:

T-cell dysregulation
Reduced Treg function
Lymphopenia
Reduced CNS iron metabolism

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) are a form of regenerative medicine that is used in both international and nationally affiliated clinics and distribution organizations to help boost the body’s own natural healing process back to its original function. HCTPs have beneficial factors as they help with repairing and regenerating damaged cells, diseased organs, and tissue back to their original function. As there is more upcoming research about the beneficial uses of HCTP, many individuals that are dealing with chronic pain can be utilized with HCTP as part of their therapy treatment, they can begin to feel pain-free and be on their wellness journey.

Viral Infections In Neurodegenerative Disorders

Since neurodegenerative and neurobehavioral diseases can be caused by infections, studies have shown that systemic viral infections can occur in neurodegenerative diseases causing the loss of neurons and axons in the central nervous system to increase with age. When this happens, the toxins bind to subunits of GM1 gangliosides which may account for elevated GM1 antibodies in ALS. The virus attaches and fuses to the host by breaking down phospholipids to produce inclusion bodies (as seen in ALS, AD, etc.) These toxins are the result in defects in ADP-ribosyltransferase (mRNA proteins) and when there is an overactivation disrupts actin cytoskeleton dynamics and nitric oxide production causing critical enzymes to be affected by Rho Kinase (ROCK). Other research studies show that when there are virus-induced alterations and neuron degenerations can be both directly and indirectly since they have the ability to attack the immune system and different regions of the nervous tissue by interfering with the same pathways that are involved with neurological diseases. These virus-induced alternations have lipid-containing membrane envelopes derived from modified cell membranes borrowed from the host via serine proteases and the primary pathology for kidnapping host DNA and RNA involves specific viral polymerases that affect host mRNA including Rho Kinase.

Fungal Pathogens Affecting Brain Health

Research studies have found that when the central nervous system is being invaded by fungal infections, it can cause an increase in morbidity in immunocompromised hosts and can lead to fatal consequences depending on the immune status and the virulence of the fungal strain. Since the fungal pathogens are airborne with hematogenous spread, fungal toxins including fumonisins alter sphingolipid metabolism which affects phospholipid metabolism, thus an increased production of excitatory neurotransmitters (ex: glutamate in ALS).

Other research studies have found that for fungal infections to occur is that they have to be “arrested” in the brain microvasculature and be transmigrated across the blood-brain barrier. When this happens, they share toxin-based homology through plasmid-mediated transfer central nervous system infections diseases must break down the blood-brain barrier via MMP-9 in a manner similar to leaky gut. The pathogenic processes begin with penetration in lipid-rich host cells and then the fungal infections will kidnap the host RNA metabolism leading to protein aggregation.

Conclusion

All in all, the central nervous system is home to the brain and spinal cord and their job are to send out trillions of neuron signals all throughout the entire body. These neuron signals make sure that everything from the gut to the body itself is functioning properly. When exposed pathogens like fungal, bacterial, and viral infections enter the body, they can attach themselves to the neuron signals and travel all the way up to the brain causing neurodegenerative diseases to develop. Incorporating antibiotics, nutritional foods, and changing a lifestyle, a person can prevent these pathogens from entering their bodies and continue on their wellness journey.

References

Dehhaghi, Mona, et al. “Microorganisms’ Footprint in Neurodegenerative Diseases.” Frontiers in Cellular Neuroscience, Frontiers Media S.A., 4 Dec. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6288487/.

Góralska, Katarzyna, et al. “Neuroinfections Caused by Fungi.” Infection, Springer Berlin Heidelberg, Aug. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6096918/.

Karim, Sajjad, et al. “The Role of Viruses in Neurodegenerative and Neurobehavioral Diseases.” CNS & Neurological Disorders Drug Targets, U.S. National Library of Medicine, 2014, pubmed.ncbi.nlm.nih.gov/25230220.

Mayne, Katie, et al. “Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?” Frontiers in Aging Neuroscience, Frontiers Media S.A., 23 Sept. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7538701/.

Shi, Meiqing, and Christopher H Mody. “Fungal Infection in the Brain: What We Learned from Intravital Imaging.” Frontiers in Immunology, Frontiers Media S.A., 2 Aug. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4969284/.

Zhou, Li, et al. “Viruses and Neurodegeneration.” Virology Journal, BioMed Central, 31 May 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3679988/.

Disclaimer

Dehydrated

Dr. Alex Jimenez

Thirsty woman drinking water to recuperate after jogging

Anybody can become dehydrated if they don’t take care of themselves and drink plenty of water. Being dehydrated happens when there is insufficient water in the body or increased water loss through sweating, vomiting, and/or diarrhea, along with certain medications, can increase urination and dehydration. Older adults have an increased risk of dehydrating because their body’s fluid reserves decrease, and their body’s ability to signal that they are thirsty does not work as effectively, especially those with memory problems.

Table of Contents

Dehydrated Symptoms

Signs of dehydration include:

Muscle cramps.
Dry mouth
Dry cough.
Tiredness/fatigue.
Flushed red skin.
Swollen feet.
High heart rate but low blood pressure.
Dizziness, weakness, light-headedness.
Headache, delirium, confusion.
Loss of appetite with a sugar craving.
Heat intolerance or chills.
Constipation.
Dark-colored urine. Urine should be a pale clear color.

Dehydration Levels

Dehydration is categorized as:

Mild

The body needs more fluids to be taken in.
Drink water
Drinks containing electrolytes are recommended if experiencing significant sweating or fluid losses from vomiting and diarrhea.
The body should feel better after five or ten minutes.

Moderate

Moderate dehydration requires intravenous hydration.
This is done in urgent care, emergency room, or a hospital.

Severe

If symptoms of dehydration are severe, call 911 or go to an emergency clinic.

Brain Health

Severe hydration shrinks the blood vessels in the brain.
When fluid levels in the brain are low, this affects memory and coordination.

Diagnosis

Laboratory tests can diagnose dehydration and include:

Low urine sodium.
Elevated plasma serum osmolality measures particle concentration in blood plasma.
Elevated creatinine tests kidney function.
Elevated blood urea nitrogen is also related to kidney function.

The amount of water needed daily is different for all individuals; therefore, it is recommended to check in with a healthcare provider to determine how much is required to maintain health.

Body Composition

Enjoy Drinking Water

Carry a water bottle, keep it filled, and get used to taking sips throughout the day to start a healthy habit.
Add flavor like a wedge of lemon/lime, lime or lemon juice, or a healthy water additive.
Choose water or healthy hot or iced tea instead of sugary drinks, including at meals.
Eat foods high in water content, like fruits and vegetables.

References

Bhave, Gautam, and Eric G Neilson. “Volume depletion versus dehydration: how understanding the difference can guide therapy.” American journal of kidney diseases: the official journal of the National Kidney Foundation vol. 58,2 (2011): 302-9. doi:10.1053/j.ajkd.2011.02.395

Centers for Disease Control and Prevention. Drinking-Water. (www.cdc.gov/healthywater/drinking/nutrition/index.html)

HealthFirst. What Happens to Your Body When You’re Dehydrated? (healthyliving.healthfirst.org/happens-body-youre-dehydrated/)

Kenefick, Robert W, and Michael N Sawka. “Hydration at the worksite.” Journal of the American College of Nutrition vol. 26,5 Suppl (2007): 597S-603S. doi:10.1080/07315724.2007.10719665

Thomas, David R et al. “Understanding clinical dehydration and its treatment.” Journal of the American Medical Directors Association vol. 9,5 (2008): 292-301. doi:10.1016/j.jamda.2008.03.006

The Reversal of Cognitive Decline In the Brain

Dr. Alex Jimenez

Table of Contents

Introduction

In the central nervous system, the brain’s primary function is to make sure that the neuron signals it’s producing are being transmitted all throughout the body. These neuron signals help with motor function, digestion function, and immune function by making sure that the entire systems inside the body are working properly. When there are neurodegenerative factors that enter the body and attach to the neuron signals, they can be disruptive and cause the brain to develop chronic issues that can make the body be dysfunctional. This is known as cognitive decline and it can range from being mild to severe over time. In this article, we will be taking a look at what is cognitive decline, its symptoms, and ways to reverse cognitive decline from progressing further in the brain. By referring patients to qualified and skilled providers who specialized in neurological services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Is Cognitive Decline?

In a normal functioning brain, it does naturally decline with age while still retaining all of its functions that make the body move, see, digest, and remember events that it went through. However, when there are disruptors that attach themselves to the neuron signals and travel through the brain, it can cause a person to momentarily forget or not retain new information. This is known as cognitive decline and research studies have found that cognitive decline can make a person frequently forget important information or conversations. This will also lead to symptoms of dementia or even Alzheimer’s disease if the cognitive decline continues to progress over time.

The Symptoms

Research shows that the many symptoms and risk factors of cognitive decline if it is not treated, can further progress cognitive degeneration until it turns chronic. As stated, the brain ages naturally causing shrinkage while maintaining information, but for a mild cognitive impairment, the brain will shrink as well but will not retain the information. Some of the symptoms and risk factors that cognitive decline cause to the brain are:

High blood pressure
Physical inactivity
Depression
Lose train of thought
Forget things more often

HCTP Therapy

HCTP (human cellular tissue products) or stem cells* are a form of regenerative medicine that is used in both international and nationally affiliated clinics and distribution organizations. The beneficial properties of HCTP provide individuals a boost in their own body’s natural healing process. HCTP’S function is to repair and regenerate damaged cells, diseased organs, and tissues back to their original functioning state in the body. With more and upcoming research discussing about the beneficial properties of HCTP, individuals can begin to get their lives back without the chronic symptoms that they are feeling.

Ways To Reverse Cognitive Decline

Since cognitive decline has become a major concern for older adults and the aging population, studies have found that cognitive decline was driven by a large part of metabolic processes that individuals were facing. By finding therapeutic ways to reverse cognitive decline from progressing further can benefit many individuals to improve their brain function and live longer as they get older. Some of the beneficial ways to reverse cognitive decline include:

Eating nutritional food
Getting an adequate amount of sleep
Exercising regularly
Meditating
Find a new hobby

Social Engagement

Research studies have found that when older adults don’t have enough social engagement, it can cause them to feel lonely and their cognitive function begins to decline. By going out and being social, many individuals will have their cognitive health be protected from pre-dementia symptoms and create new memories. Other studies have shown that older adults who are more socially engaged tend to have a high cognitive function than older adults who don’t socially engage with other people. Meeting new people and having a conversation with them is a great way to reverse cognitive decline.

Eating Nutritious Food

Incorporating nutritional brain food can help boost the brain’s neuron signals and even dampen the effects of cognitive decline as well as many other symptoms that may cause the body harm. Research studies have shown that low glycemic index foods can help improve the attention, memory, and functional capacity of the brain. By incorporating nutritional foods that can give the brain boosted energy, many individuals can begin to eat healthier and dampen unwanted pathogens that they didn’t know that they had. Other studies have found that the Mediterranean diet can correlate with improving cognitive function. The Mediterranean diet has many beneficial properties as it is consist of whole fruits and vegetables, whole grains, nuts, legumes, fish, and olive oil and can even help lower inflammatory responses that are affecting the joints, the gut, and the brain as well.

Mental & Physical Exercise

Studies have found that any type of exercise whether it is physical or mental can help exert effects on cognitive function by affecting the molecular events in the brain’s management of energy metabolism and synaptic plasticity. By exercising the body, the brain will start to remember how each rep works and the motor function will start to remember the repetitive motions that a person is doing as they are working out. Now by mentally working out the brain is another way to reverse the effects of cognitive decline provides the same results. Research has found that by intellectually engaging the brain can help reduce oxidative stress and help improve memory for older adults. This can be numerous of activities like, reading a new book, learning a new skill, taking a class, dancing, or learning to play music can help improve the quality of life for many individuals.

Conclusion

All in all, by finding ways to reverse the effects of cognitive decline from the brain can help many individuals. Whether it is eating the right food, exercising both mentally and physically, being engaging in a social gathering can help improve brain function and a person’s quality of life. Since the brain is part of the central nervous system, many individuals can make these small changes in their lifestyle and begin to see a change in themselves in a more positive way.

References

Bredesen, Dale E. “Reversal of Cognitive Decline: A Novel Therapeutic Program.” Aging, Impact Journals LLC, Sept. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4221920/.

Gomez-Pinilla, Fernando, and Charles Hillman. “The Influence of Exercise on Cognitive Abilities.” Comprehensive Physiology, U.S. National Library of Medicine, Jan. 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3951958/.

Krueger, Kristin R, et al. “Social Engagement and Cognitive Function in Old Age.” Experimental Aging Research, U.S. National Library of Medicine, 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2758920/.

Martínez García, Rosa María, et al. “[Nutrition Strategies That Improve Cognitive Function].” Nutricion Hospitalaria, U.S. National Library of Medicine, 7 Sept. 2018, pubmed.ncbi.nlm.nih.gov/30351155/.

Medical Professionals, Cleveland Clinic. “Mild Cognitive Impairment: Symptoms, Causes, Treatments & Tests.” Cleveland Clinic, 18 Mar. 2019, my.clevelandclinic.org/health/diseases/17990-mild-cognitive-impairment.

Medical Professionals, NIA. “Cognitive Health and Older Adults.” National Institute on Aging, U.S. Department of Health and Human Services, 1 Oct. 2020, www.nia.nih.gov/health/cognitive-health-and-older-adults.

Medical Professionals, NIH. “Diet May Help Preserve Cognitive Function.” National Institutes of Health, U.S. Department of Health and Human Services, 14 Apr. 2020, www.nih.gov/news-events/news-releases/diet-may-help-preserve-cognitive-function.

National Research Council (US) Committee on Aging Frontiers in SocialPsychology, et al. “Social Engagement and Cognition.” When I’m 64., U.S. National Library of Medicine, 1 Jan. 1970, www.ncbi.nlm.nih.gov/books/NBK83766/.

Staff, Mayo Clinic. “Mild Cognitive Impairment (MCI).” Mayo Clinic, Mayo Foundation for Medical Education and Research, 2 Sept. 2020, www.mayoclinic.org/diseases-conditions/mild-cognitive-impairment/symptoms-causes/syc-20354578.

Disclaimer

Functional Neurology and ALS | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

The central nervous system consists of the brain and the spinal cord that makes sure that neuron signals are being transmitted all over the body and making sure that it’s working properly. These neuron signals make sure that the gut system, the cardiovascular system, the immune system, and even the endocrine system are working properly and that the neuron signals are being transferred back to the brain with the information. When there are unwanted pathogens that start to attach themselves to the neuron signal, it can cause a disruption to the brain causing neurological disorders to develop over time and wreak havoc on the brain. In this 2 part series, we will be taking a look at what ALS is and how functional neurology diagnoses ALS. Part 1 took a look at what is functional neurology, its relationship with functional medicine, and how functional neurology can help dampen the effects of neurological disorders. By referring patients to qualified and skilled providers who specialized in neurological services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Is ALS?

ALS(Amyotrophic Lateral Sclerosis) or as it is commonly known as “Lou Gehrig’s” disease is a progressive nervous system disease that affects the nerve cells in both the brain and spinal cord, as research shows. Since amyotrophic come from Greece, it means that there is “no muscle nourishment” while lateral identifies the area of the spinal cord where portions of the nerve cells that signal and control muscles, called motor neurons are located and sclerosis refers to scarring or hardening in the region of the lateral spinal cord.

By putting the entire words together, ALS means that there is no nourishment to the motor neurons that are located in the spinal cord. Research also shows that ALS actually belongs to a wide group known as motor neuron diseases that causes gradual degeneration and eventually death to the motor neuron signals and over time cause the brain to lose the ability to control voluntary movements to the body.

The Symptoms

Research has found that ALS affects both the upper and lower motor neurons causing them to decline gradually until they can’t send signals to the muscles. The lower limbs will begin to cause a person to trip, stumble, make them feel really awkward when they are running. When this happens to the lower limbs, the foot will drop or cause a slapping gait. While the upper limbs will cause reduced finger dexterity, cramping, stiffness, and weakness of the intrinsic hand muscles. This will cause a person to have difficulty doing everyday tasks like buttoning clothes, picking up small objects, or turning a key. Other symptoms that ALS causes on the body include:

Muscle weakness
Difficulty with speech and swallowing
Unsteadiness
Spastic tone
Brisk or depressed deep tendon reflexes (maybe a mixture of both)
Muscle atrophy
Fasciculations

ALS & Cell Death

So caspases are a family of protein‐cutting enzymes that plays a key role in apoptosis, which is the removal of unwanted or damaged cells. Studies have shown that apoptosis occurs naturally and is normal during the development, aging, and homeostatic mechanism to maintain the body’s cellular population in the muscle tissue. Apoptosis is also a defense mechanism for the immune system when cells are being damaged by diseases or toxins. When apoptosis is activated, caspases initiate “death” programs (apoptosis) by destroying key components of the cellular infrastructure and activating factors that mediate damage to the cells. The caspases then let the upstream initiators (activated by the cell‐death signal, e.g., TNF‐alpha) and downstream executioners (directly mediate the events that lead to the demise of the cell). Once that is done, then the executioner caspases activate the machinery that degrades DNA – one example is caspase‐3.

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) have been used in affiliated clinics and distribution organizations (both international and national) in regenerative cellular treatment. What HCTP does is that it helps boost the body’s own natural healing process by regenerating and repairing damaged cells, diseased organs, and tissues back to their original state and function. With more and upcoming research on the beneficial uses of HCTP, many individuals will begin to feel pain-free and continue on their wellness journey.

Functional Neurology & ALS

In part 1, it discussed what functional neurology is and how it is used to diagnose many neurological disorders that are affecting the brain and the body. Since ALS is a progressive neurodegenerative disease that causes muscle failure, research shows that the use of functional neurology can provide both the patients and medical professionals many opportunities to improve the diagnosis and even establish candidate biomarkers for future therapeutic strategies to dampen the progression of ALS.

Nutrition & ALS

When individuals are suffering from ALS, research shows that ALS increases the high risk of malnutrition causing symptoms of dysphagia, depression, cognitive impairment, difficulty with self‐feeding and meal preparation, hypermetabolism, anxiety, respiratory insufficiency, and fatigue with meals to individuals. However, incorporating nutritional foods that are higher in antioxidants and fiber‐rich foods such as fruit and vegetables can reduce the risk of ALS. Even consuming foods high in ω‐3 PUFAs may help prevent or delay the onset of ALS.

Exercise & ALS

Moderate exercise has been shown to improve strength and prolong survival in animal models of ALS and should not be avoided. Studies have found that proper exercise is highly important for preventing atrophy of the muscles, particularly in the early stages of ALS. Sedentary behavior leads to deconditioning and weakness caused by the disease itself, thus contributing to muscle and joint tightness, contractures, and pain. Some of the benefits of moderate exercise can help increase appetite, digestion, mood, sleep, positive impact on hormones/trophic factors (including BDNF and IGF‐1), and inflammatory markers. However, if a person has fatigue or pain that lasts longer than 30 minutes after exercise, the program needs to be reduced and modified but still, give beneficial results.

Conclusion

All in all, ALS is a progressive neurological disease that causes muscle failure in the body. By utilizing functional neurology and creating a treatment plan on dampening the progressive effects, many individuals can be pain-free and feel great. Even though ALS is chronic and there is no cure yet, by making small changes in the food a person eats and incorporating moderate exercises, the body has a chance to live longer.

References

de Almeida, J P Lopes, et al. “Exercise and Amyotrophic Lateral Sclerosis.” Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, U.S. National Library of Medicine, Feb. 2012, pubmed.ncbi.nlm.nih.gov/22228269/.

Dharmadasa, Thanuja, et al. “Implications of Structural and Functional Brain Changes in Amyotrophic Lateral Sclerosis.” Expert Review of Neurotherapeutics, U.S. National Library of Medicine, 19 Apr. 2018, pubmed.ncbi.nlm.nih.gov/29667443/.

Elmore, Susan. “Apoptosis: A Review of Programmed Cell Death.” Toxicologic Pathology, U.S. National Library of Medicine, June 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC2117903/.

Medical Professional, NINDS. “Amyotrophic Lateral Sclerosis (ALS) Fact Sheet.” National Institute of Neurological Disorders and Stroke, U.S. Department of Health and Human Services, 26 Apr. 2021, www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet.

Medical Professionals, Cleveland Clinic. “Amyotrophic Lateral Sclerosis: What Is It, Symptoms & Management.” Cleveland Clinic, 15 June 2021, my.clevelandclinic.org/health/diseases/16729-amyotrophic-lateral-sclerosis-als.

Nieves, Jeri W, et al. “Association between Dietary Intake and Function in Amyotrophic Lateral Sclerosis.” JAMA Neurology, U.S. National Library of Medicine, 1 Dec. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5370581/.

Staff, Mayo Clinic. “Amyotrophic Lateral Sclerosis (ALS).” Mayo Clinic, Mayo Foundation for Medical Education and Research, 22 Feb. 2022, www.mayoclinic.org/diseases-conditions/amyotrophic-lateral-sclerosis/symptoms-causes/syc-20354022.

Disclaimer

An Insight View On Functional Neurology | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

The brain is part of the central nervous system where its main function is to send out neuron signals all throughout the body in a bidirectional connection as it sends the information back. When there are unwanted pathogens that disrupt the neuron signals, it can cause the entire body to be dysfunctional and cause unwanted problems to the brain, gut, musculoskeletal, and immune system. Through the use of functional neurology, many healthcare providers have found ways to help individuals by dampening the effects of neurological disorders from progressing further. In this 2 part series, we will be taking a look at what is functional neurology, its relationship with functional medicine, and how functional neurology can help dampen the effects of neurological disorders. In Part 2, we will take a look at what is ALS and how functional neurology diagnoses ALS. By referring patients to qualified and skilled providers who specialized in neurological services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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What Is Functional Neurology?

So functional neurology is a branch of medicine that deals with disorders of the nervous system. Functional neurology deals with the diagnosis and treatment of all categories of conditions and diseases involving the central and peripheral nervous systems, including their coverings, blood vessels, and all effector tissue, such as muscle. Studies have found that functional neurology is one of the many specialties that are within the world of chiropractic practices. Within chiropractic practice, many chiropractors will start manipulating the spine on patients causing a sense of relief on the spinal nerves. When the spinal nerves are disrupted it causes an imbalance to the nerve output in the body, thus resulting in an unhealthy body and chronic neurological disorders will develop over time.

What Is Functional Medicine?

Functional medicine is system biology that is based on an approach and focuses on identifying and addressing the root cause of disease. Since each symptom or differential diagnosis may be one of many
contributing to an individual’s illness. Research studies show that functional medicine is represented as a therapeutic partnership between the patient and the practitioner that focuses on the underlying causes of many diseases from a systems biology perspective.

How Do They Work Together?

This combination of neurology with functional medicine demands that everyone should understand the disease that they are experiencing, understand the diagnosis which includes the natural history of the disease and standards of care in managing the disorder, along with the ability to consider the unique factors that cause the disease in the individual patient. What this means is that talking with a healthcare provider about what is making a person feel horrible can provide them with the answers that they have been searching for. With the application of functional medicine and functional neurology combined, is how many providers guide the patient through a program that ultimately accomplishes a change in the disease trajectory and a transformation of the individual affected by the disease (functional medicine). Some the examples that functional neurology and medicine actually look include:

Mental Status
Cranial Nerves
Motor Examination
Bulk, Tone, Power
Coordination
Sensation
Pain/Temperature
Vibration/Proprioception
Deep Tendon Reflexes and Primitive Reflexes
Gait and Station

HCTP Therapy

Stem cells* or HCTP (human cellular tissue products) are part of regenerative cellular treatment that helps boost the body’s own natural healing process. Both international and nationally affiliated clinics and distribution organizations use HCTP to help repair and regenerate damaged cells, diseased organs, and tissues back to their original function in the body. With many upcoming research studies about the beneficial factors of HCTP, many individuals can begin their wellness journey pain-free from chronic disorders.

Functional Neurology & Neurological Diseases

Since functional neurology deals with diagnosing and treating neurological disorders, research has shown that functional neurological disorders are related to how the brain functions and not to the damage that was caused to the brain’s structure. With this, many healthcare providers can give patients an early diagnosis and treatment to help with the recovery process. Other research studies have also found that when someone has functional neurological disorders, they can function normally like everybody else, however, their brain is unable to send and receive the neuron signals properly causing a disconnection to the lobes’ function and emotional processing in the brain.

Functional Neurology & Alzheimer’s Disease

So the term “Alzheimer’s disease” actually refers to an aggregate of neuropathologic changes and thus is defined in vivo by biomarkers and by postmortem examination, not by clinical symptoms. Research studies have shown that Alzheimer’s disease is a progressive neurological disorder that causes the brain to go into atrophy and causes the brain cells to die. As a common form of dementia, Alzheimer’s disease causes deficits in two or more areas of cognition, and it progressively worsening of memory and other cognitive functions. There are no actual disturbances of consciousness as more studies show that the manifestations of Alzheimer’s include the disturbances in the brain’s area where memory and language do function. Alzheimer’s disease occurs between ages 40 and 90, most often after age 65; and with the absence of systemic disorders or other brain diseases that in and of themselves could account for the
progressive decline in memory and cognition due to this progressive neurological disorder.

Functional Neurology & Chronic Inflammation

Inflammation in the body in its acute form is beneficial as it makes sure that it repairs the damaged area. As research studies have shown that inflammation is a fundamental, complex response that eliminates infections and the initial cause of cell injury. Even though it is beneficial in its acute form when it turns into chronic inflammation it can cause tissue damage to the organs and can affect the brain. This is known as neuroinflammation and studies have shown that neuroinflammation is an inflammatory response that is within the brain or the spinal cord. When the inflammatory cytokines are attaching themselves to the neuron signals, it can weaken the blood-brain barrier and cause many unwanted symptoms to the brain. Some of the risk factors that can cause inflammation include:

Poor sleep habits
Eating inflammatory foods
Sedentary lifestyle
Chronic stress
Social isolation
Environmental toxins
Chronic infections

Conclusion

All in all, functional neurology helps deal with the diagnosis and treatment of neurological disorders in the brain. When there are neurological disorders like Alzheimer’s disease and chronic neuroinflammation that are causing the brain to stop sending the neuron signals all throughout the body, can cause it to develop into chronic illnesses over time. Through the combination of functional neurology and functional medicine, many health care providers can help many individuals understand what is happening and can guide them on their wellness journey to be pain-free.

References

Bland, Jeffrey. “Functional Medicine: An Operating System for Integrative Medicine.” Integrative Medicine (Encinitas, Calif.), InnoVision Professional Media, Oct. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4712869/.

DiSabato, Damon J, et al. “Neuroinflammation: The Devil Is in the Details.” Journal of Neurochemistry, U.S. National Library of Medicine, Oct. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5025335/.

Margach, Russell W. “Chiropractic Functional Neurology: An Introduction.” Integrative Medicine (Encinitas, Calif.), InnoVision Health Media Inc., Apr. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6413643/.

Medical Professionals, NINDS. “Functional Neurologic Disorder.” National Institute of Neurological Disorders and Stroke, U.S. Department of Health and Human Services, 2 Aug. 2021, www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Functional-Neurologic-Disorder.

Schachter, Armand S, and Kenneth L Davis. “Alzheimer’s Disease.” Dialogues in Clinical Neuroscience, Les Laboratoires Servier, June 2000, www.ncbi.nlm.nih.gov/pmc/articles/PMC3181599/.

Skaper, Stephen D, et al. “An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.” Frontiers in Cellular Neuroscience, Frontiers Media S.A., 21 Mar. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/.

Staff, Mayo Clinic. “Alzheimer’s Disease.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 19 Feb. 2022, www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447.

Staff, Mayo Clinic. “Functional Neurologic Disorder/Conversion Disorder.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Jan. 2022, www.mayoclinic.org/diseases-conditions/conversion-disorder/symptoms-causes/syc-20355197.

Introduction

What Does The Liver Do?

HCTP Therapy

What Is NAFLD?

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The Symptoms

How To Treat Liver Disease?

Exercise

Conclusion

References

Disclaimer

Introduction

The Gut-Brain Connection

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HCTP Therapy

The Factors That Affect The Gut-Brain

Visceral Pain

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Stress

Inflammation

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Conclusion

References

Disclaimer

Introduction

What Is The Gut-Brain Axis?

The “Forgotten Organ”

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HCTP Therapy

Diversity Is The Key For Gut Health

Neurodevelopment & The Gut

Microbiota Regulates Anxiety

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Conclusion

References

Disclaimer

Introduction

The Roles Of GI Microbiota

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HCTP Therapy

Ways To Improve GI Microbiota

Stop Taking Antibiotic

Berberine

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Probiotics

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Conclusion

References

Disclaimer

Introduction

What Is The GI Tract Function?

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Digestion and Absorption

Enteroendocrine Cells

HCTP Therapy

Is It Interface Or Barrier In The Gut?

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Tight Junction

Paneth Cells

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Conclusion

References

Disclaimer

Spondylitis Anti-Inflammation Diet

Diet and Inflammation

Foods To Eat

Leafy greens

Cruciferous vegetables

Allium Vegetables

Berries

Fruits

Healthy oils

Nuts and seeds

Fatty fish

Avoid These Foods

Body Composition

What Happens To The Body When Eating Fruit

References

Introduction

What Is Neurodegenerative Disease?