How Probiotics Dampen Gut Disorders | Part 2

Table of Contents

Introduction

The gut system’s primary function is to make sure that the consumed food that a person eats is digested in the stomach, and the intestines (both large and small) and is absorbed into nutrients for the entire body to stay functional. The gut microbiota makes sure that the body’s energy, growth, metabolism, and immune support are doing their jobs correctly and that the bacteria in the gut are thriving. When harmful bacteria start to disrupt the balance in the intestines, it can cause many chronic gut disorders in the gut system. However, incorporating probiotics into a healthy diet can help alleviate the symptoms by dampening their effects on the gut. In this 2 part series, we will be looking at how probiotics can help dampen the impact of gut disorders. Part 1 looked at what probiotics are and how they alter the gut microbiome. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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How Probiotics Help The Gut Microbiota

The gut microbiota makes sure that the entire body is functioning properly by regulating the body’s growth, metabolism, and immune support. When probiotics enter the gut system, they provide a protective barrier to prevent intestinal permeability from getting disrupted. Research studies have found that intestinal microbes can convert dietary nutrients into metabolites. When probiotics are introduced into the gut microbiota and can help restore the composition of the gut. When there are factors that can affect the probiotic function, they are often defined as subjects that are “permissive” or “resistant” to probiotic strains based on:

Pre-Supplementation Commensal Microbiota: Species in low abundance in a given region were more permissive to similar probiotic strains.
Host immune System Function
Digestive Functions
Xenobiotic Metabolic Pathways

Other research studies have found that probiotics are live microorganisms found in fermented foods with many beneficial properties for the gut microbiota. Probiotics exhibit a variety of health beneficial properties for the gut as these microorganisms can prevent bowel diseases, improve the immune system, and prevent intestinal disorders’ effects on the digestive system.

Helping The Gut With Bugs

Your Gut Microbiome: The Most Important Organ You’ve Never Heard Of | Erika Ebbel Angle | TEDxFargo

Research studies have found that probiotics play many significant roles in the gut microbiota composition while also inhibiting the colonization of pathogenic bacteria in the intestines. Since the gut microbiota contains a rich, diverse microbial ecosystem that can influence the health of the human body, so adding probiotics to combat the overflow of harmful bacteria infesting the intestinal walls can provide beneficial relief and help regulate the gut microbiota. The probiotics will also help the body build a healthy intestinal mucosa protective layer while enhancing the immune system. Because of the close relationship between the immune system and the gut microbiota, probiotics are highly effective in improving immunity and regulating the gut microbiome.

Therapeutic Uses For Probiotics On Gut Disorders

Since the gastrointestinal (GI) tract is home to trillions of bacteria (both good and bad), there must be a balance between good and bad bacteria. These bacteria ensure that the gut microbiota is working correctly and prevent chronic gut disorders from inflicting on the intestinal wall barriers. Research studies have stated that the perturbation of the bacterial microflora of the GI tract may play an essential role in the pathophysiology of GI disorders. Using probiotics as a part of a healthy diet can help dampen the effects of GI disorders by regulating the gut flora back to normal. Some of the therapeutic use that probiotics can help the gut microbiota when it comes to gut disorders include:

Constipation
Diarrhea (traveler’s, AAD, CDAD)
IBS/SIBO
IBD
Candida
H.pylori
GERD
Intestinal Permeability

Probiotics & IBD

Research studies have found that an altercation of the mucosal immune response to bacterial agents will lead to chronic intestinal inflammation that can characterize IBD (inflammatory bowel disease). Probiotics are safe for most individuals who have IBD and those with IBS (irritable bowel syndrome). Other research studies have stated that when IBD individuals start to take probiotics can help normalize the gut barrier function and reduce the pro-inflammatory cytokines while lessening the disease. By taking probiotics, many individuals suffering from IBD will notice that their symptoms will diminish over time and that there will be positive outcomes seen at both low and high doses.

Conclusion

The gut system’s main job is to make sure that the food is being digested into nutrients and absorbed into the bloodstream to be transported throughout the entire body. When harmful pathogens enter the gut system, they can cause many digestive disorders that can upset the bacterial balance in the gut flora. When left untreated, it can develop into chronic gut diseases over time, causing the individual pain. Incorporating probiotics into a person’s diet can provide the beneficial results that a person needs. Probiotics can help replenish the healthy gut bacteria back to normal while dampening the effects of gut disorders from reoccurring in the intestinal tract. When individuals use probiotics as part of their diet, their gut will start to feel better and without pain.

References

Guandalini, Stefano, and Naire Sansotta. “Probiotics in the Treatment of Inflammatory Bowel Disease.” Advances in Experimental Medicine and Biology, U.S. National Library of Medicine, 2019, pubmed.ncbi.nlm.nih.gov/30632114/.

Hemarajata, Peera, and James Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology, SAGE Publications, Jan. 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3539293/.

Jonkers, Daisy, and Reinhold Stockbrügger. “Probiotics and Inflammatory Bowel Disease.” Journal of the Royal Society of Medicine, The Royal Society of Medicine, Apr. 2003, www.ncbi.nlm.nih.gov/pmc/articles/PMC539443/.

Shi, Lye Huey, et al. “Beneficial Properties of Probiotics.” Tropical Life Sciences Research, Penerbit Universiti Sains Malaysia, Aug. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5031164/.

Verna, Elizabeth C, and Susan Lucak. “Use of Probiotics in Gastrointestinal Disorders: What to Recommend?” Therapeutic Advances in Gastroenterology, SAGE Publications, Sept. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3002586/.

Wang, Xinzhou, et al. “Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity.” Molecules (Basel, Switzerland), MDPI, 8 Oct. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8512487/.

Disclaimer

How Probiotics Alter The Gut Microbiome | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

When a person consumes food, it is traveled down to the gut system, where it can be digested and biotransformed into nutrients in the small and large intestines. These nutrients are then absorbed into the bloodstream and are transported throughout the entire body. These nutrients help the digestive system and provide immune support, metabolism, and body growth while helping to regulate the functions of the endocrine system, the central nervous system, and the musculoskeletal system. There are ways to optimize gut health as there are harmful pathogens that can disrupt the gut system through the usage of probiotics. In this 2 part series, we will be looking at what probiotics are and how they alter the gut microbiome. Part 2 will look at how probiotics can help dampen the effects of gut disorders. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Are Probiotics?

The generic definition of probiotics is defined as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host.” Research studies have also stated that probiotics contain live microorganisms intended to maintain or even improve the beneficial bacteria in the gut system. Probiotics make sure that there is a balance of bacteria in the gut as different strands are there to prevent the harmful bacteria from overtaking the gut and intestines, causing a variety of gut disorders. Other research studies have found that there is a range of diseases that are associated with the gut and intestinal tract and when a person uses probiotics will help suppress unwanted gut symptoms.

However, some foods do not have probiotics strains like food-borne bacteria (e.g., the dirt on vegetables) or even fermented foods that are naturally occurring or starter cultures. Some probiotic strains are added to fermented food after they have been pasteurized, and these can include yogurt or kefir as probiotics.

Are Fermented Foods Probiotics?

When probiotic strains are added to fermented foods, they can provide beneficial bacteria to the gut and help dampen the effects of various gut disorders. Fermented foods contain natural (or added) cultures designed to digest the food during fermentation, creating organic acids and other byproducts. However, not all fermented foods are probiotics, as these organisms are often absent from the consumed product. This is primarily due to the storage and packaging of fermented foods in containers. A few controlled trials of fermented foods have been performed to document their traditional benefits. Research studies have shown that fermented foods contain microorganisms that can reach the gastrointestinal tract and potentially affect cardiovascular, immune, and metabolic health by generating bioactive peptides and polyamines. Many individuals with gut issues should be encouraged to incorporate fermented foods into their diet but not use them as a therapeutic substitute for probiotics.

An Overview Of Probiotics

What Are Probiotics? | GutDr Mini-Explainer

Since probiotics are live microorganisms that exhibit a wide variety of beneficial health properties for the gut, as studies have shown, probiotics can help dampen the effects of gastrointestinal disorders while also improving the immune system and producing more beneficial bacteria for the gut flora. Probiotics are excellent for gut health as they have different strains to help fight off harmful bacteria that can cause infections and chronic disorders to the gut and the body. Probiotics are also found in fermented foods like kimchi, yogurts, and kefir that can affect cardiovascular, immune, and metabolic health with the bioactive peptides and polyamines that it generates.

How Probiotics Alter The Gut Microbiome

When probiotics enter the gut microbiome, the strains are thought to be highly domesticated cousins from a fraction of the total gut “wild-type” microbiota. Research studies have found that when probiotics are being ingested, they cause significant positive improvements in balancing intestinal permeability and barrier function in the gut system. Not only that, but probiotics can also provide a considerable balance to the gut microbiota and brain functionality. The gut-brain axis needs probiotics to make sure that everything is functioning correctly. Probiotics act as part of the temporary or transient gut microbiota when consumed. Other research studies have found that the impact of probiotics does not reside in the ability to graft in the gut microbiota. They share genes and metabolites while supporting a challenged gut microbiota dealing with gut and gastrointestinal disorders by directly influencing the epithelial and immune cells in the gut and the body.

Conclusion

Utilizing probiotics in a healthy diet can help promote optimal gut health by lowering the effects of harmful bacteria affecting intestinal permeability. When unhealthy bacteria cause havoc to the gut microbiota, it can affect the body as well. The gut is home to all the body’s functions as the gut helps maintain the body’s energy, growth, metabolism, and immune support by keeping the body and the other systems functional. Therefore, probiotics are beneficial to the gut microbiota as they help dampen the effects of the gut and gastrointestinal disorders that are causing discomfort in the gut. Many individuals can incorporate probiotics in food or supplement form to ensure that their gut is happy and filled with beneficial bacteria to support them.

References

Bell, Victoria, et al. “One Health, Fermented Foods, and Gut Microbiota.” Foods (Basel, Switzerland), MDPI, 3 Dec. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6306734/.

Dimidi, Eirini, et al. “Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease.” Nutrients, MDPI, 5 Aug. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6723656/.

Shahrokhi, Mahsa, and Shivaraj Nagalli. “Probiotics – Statpearls – NCBI Bookshelf.” StatPearl [Internet] Treasure Island (FL), StatPearls Publishing, 25 Nov. 2021, www.ncbi.nlm.nih.gov/books/NBK553134/.

Shi, Lye Huey, et al. “Beneficial Properties of Probiotics.” Tropical Life Sciences Research, Penerbit Universiti Sains Malaysia, Aug. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5031164/.

Wieërs, Grégoire, et al. “How Probiotics Affect the Microbiota.” Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A., 15 Jan. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC6974441/.

Zeratsky, Katherine. “Probiotics and Prebiotics: What You Should Know.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 10 July 2020, www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/probiotics/faq-20058065.

Disclaimer

Stress Health

Dr. Alex Jimenez

chiropractor in white coat massaging neck of man

Stress health recognizes how stress affects the body, thoughts, feelings, and behavior. Stress that’s left untreated can contribute to various health problems. These include:

Anxiety
Decreased energy levels
Digestive dysfunction
Obesity
Diabetes
High blood pressure
Abnormal heart rate
Heart disease
Mental problems

Chiropractic serves as a powerful intervention for anxiety-related symptoms.

Table of Contents

Stress Health Blood Pressure and Heart Rate Balance

Chiropractic benefits cardiovascular health as it directly affects the nervous and other body systems that include the spinal system, the bones, joints, and muscular system, affecting the function of the cardiovascular system. Chiropractic regulates these system’s functions allowing for a moderate heart rate and blood pressure. Balanced blood pressure and heart rate can help minimize stress and anxiety, making it much easier to stay relaxed and focused. Individuals report experiencing decreased blood pressure and lower heart rate with long-term chiropractic treatment.

Mental Clarity

Cerebrospinal fluid/CSF is necessary for detoxifying the brain and helping to protect the brain. CSF transports oxygen and nutrients to the brain, helping to increase brain function efficiency. Chiropractic has been shown to increase the amount of cerebrospinal fluid delivered to the brain. This is because the spine is aligned correctly, allowing for a smooth flow of blood and nerve energy from the brain through the spine to the rest of the body. This provides:

Sustained mental alertness
Awareness
Mental Clarity

This helps to combat mental fog or anxiety hyperactivity.

Improve Energy Levels

Chiropractic can help increase energy levels in different ways for different individuals.

For some, this works by eliminating headaches, migraines, and other nerve dysfunction/s.
For others, this happens by decreasing or eliminating pain symptoms.

These conditions can contribute to lowered energy levels. Constant stress can change the body’s chemistry, leading to increased stress hormones like cortisol. Over time, these hormone releases can decrease energy, causing interference with the body/brain’s natural rejuvenating processes that reduce stress. With chiropractic, the therapeutic effects help correct body chemistry and improve energy levels.

Body Composition

Increase Immune Function

Lymphatic fluid has a vital role in stress health and the function of the immune system. Lymphatic fluid helps separate and release:

Toxins
Viruses
Fungus
Bacteria from the body.

When lymphatic fluid flows smoothly and is not impeded or trapped in tissues, joints, or muscles, the immune system operates at a high level. Chiropractic helps drive lymphatic fluid out of the tissues, joints, and muscles of the body, facilitating optimal immune function.

References

Dragoş, Dorin, and Maria Daniela Tănăsescu. “The effect of stress on the defense systems.” Journal of medicine and life vol. 3,1 (2010): 10-8.

Meier, Jacqueline Katharina et al. “Stress Alters the Neural Context for Building New Memories.” Journal of cognitive neuroscience vol. 32,12 (2020): 2226-2240. doi:10.1162/jocn_a_01613

Pickar, Joel G. “Neurophysiological effects of spinal manipulation.” The spine journal: official journal of the North American Spine Society vol. 2,5 (2002): 357-71. doi:10.1016/s1529-9430(02)00400-x

An Overview Of Therapeutic Treatments For SIBO | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

The gut system is home to the organs and intestines that ensure that the consumed food is digested and absorbed into the bloodstream while being transported throughout the entire body. The gut system makes sure that the energy, growth, metabolism, and immune support are provided to the body and the immune system, endocrine system, and even the central nervous system for optimal performance. When pathogens enter the gut system, they can cause a variety of gut disorders like SIBO (small intestinal bacterial growth) to cause havoc in the gut system and cause the body to be dysfunctional. In this 2 part series, we will be looking at different treatments for SIBO and SIFO to optimize gut health. In Part 1, we looked at how SIBO and SIFO affect the gut and their symptoms. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

SIBO/SIFO & The Intestines

In the gut, trillions of bacteria live in the stomach and intestines that help make sure that the food is digested and absorbed into the bloodstream as nutrients. These bacteria help keep the gut and intestines healthy and the body functioning as they help regulate the digestive system. The intestines are the primary reason nutrients are absorbed into the bloodstream. When there is an overabundance of bacteria and fungi species in the intestines causing the gut to be dysfunctional, it’s known as SIBO (small intestinal bacterial overgrowth) and SIFO (small intestinal fungal overgrowth). Part 1 looked at what SIBO and SIFO are and how their symptoms impact the gut. Research shows that SIBO is a commonly diagnosed gastrointestinal disorder that causes maldigestion and malabsorption in the intestines. When there are more bad bacteria than good, it can cause gastrointestinal symptoms like gas, bloating, and abdominal pain in the gut system and overlap with gastrointestinal disorders causing gut discomfort. Hence treatments can help with eliminating SIBO and SIFO out of the intestines and provide relief to the gut.

How To Treat SIBO

Research studies have shown that SIBO is considered one of the manifestations of gut microbiome dysbiosis and can be highly prevalent in IBS (irritable bowel syndrome). When SIBO starts to affect the gut and the intestines, it can cause many gastrointestinal disorders and cause the body to be dysfunctional. There are ways to treat SIBO from reoccurring in the intestines as therapeutic options can help lower the harmful bacterial growth and replenish the good bacteria back in the gut. Once a person utilizes treatment to their gut by getting rid of the excess amount of harmful bacteria, they can continue their wellness journey without gut issues.

Therapeutic Treatments For SIBO/SIFO

There are many ways to ensure that SIBO and SIFO will be eliminated from the body. Research studies show that many doctors will treat SIBO by utilizing treatments more focused on correcting the nutritional deficiencies and eliminating the bacterial overgrowth taking over the intestines. The goal here is to treat the underlying causes, contain the bacterial overgrowth, and provide nutritional support for the gut when SIBO and SIFO affect it. Some of the therapy treatments that are used to treat SIBO and SIFO in the intestines include:

Diet (low FODMAPs)
Antibiotic therapy (Weeding)
Prokinetic agents
Herbs for weeding* (berberine, oregano oil, wormwood)
Probiotics (multiple mechanisms)
Serum Bovine-derived Immunoglobulins (SBIs)
Enzymes/HCl
Other(Antrantil, SYN-001:)

Probiotics

Research studies have found that probiotics can provide health benefits to the body. When a person has SIBO in their gut, antibiotics can help eliminate the harmful bacteria; however, that can cause antibiotic resistance and recolonize the harmful bacteria. Probiotics are living organisms with unique beneficial properties that can produce good bacteria to get rid of the harmful bacteria out of the intestines, enhance the mucosal barrier function, and even downregulate inflammatory responses that affect the gut. Probiotics are necessary for promoting gut health as part of the 5Rs program for repairing a dysfunctional gut.

Healthy Diet

Eating healthy food can help many individuals that are suffering from SIBO. Research studies have found that having a healthy diet can provide alterations and induce significant, temporary microbial shifts in 24 hours. Eating the right kinds of food that help promote gut health and offer nutrients to the body can lower the reoccurrence of SIBO from coming back. When a person makes small changes in their eating habits, it can provide excellent results as the body needs these nutrients from whole fruits and vegetables. Other research studies have found that the gut microbiome plays a vital role in human health as dietary patterns and environmental factors profoundly shape gut microbiota. When a person doesn’t change their eating habits and continues to eat processed food, their gut, and the bacteria microbiome will cause chronic issues to pop up over time. When they make those necessary changes in their eating habits, the gut microbiome will produce more beneficial bacteria for the nutrients to be absorbed.

Conclusion

Overall, the gut system makes sure that the bacteria in the intestines take the digested food and transform them into nutrients to be absorbed into the bloodstream and make the body functional. When gastrointestinal disorders like SIBO start to affect the intestines, it can cause the development of chronic conditions to affect not just the gut but also the body. Incorporating a healthy diet with gut-healthy food, taking probiotics, and finding ways to lower gut inflammation can help many individuals take care of their gut microbiota and produce more beneficial bacteria in the intestinal tract. With these treatments, a person can continue their wellness journey without gut issues affecting them.

Reference

Achufusi, Ted George O, et al. “Small Intestinal Bacterial Overgrowth: Comprehensive Review of Diagnosis, Prevention, and Treatment Methods.” Cureus, Cureus, 27 June 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7386065/.

Chen, Wei Chung, and Eamonn M M Quigley. “Probiotics, Prebiotics & Synbiotics in Small Intestinal Bacterial Overgrowth: Opening up a New Therapeutic Horizon!” The Indian Journal of Medical Research, Medknow Publications & Media Pvt Ltd, Nov. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4311309/.

Hills, Ronald D, et al. “Gut Microbiome: Profound Implications for Diet and Disease.” Nutrients, MDPI, 16 July 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6682904/.

Singh, Rasnik K, et al. “Influence of Diet on the Gut Microbiome and Implications for Human Health.” Journal of Translational Medicine, BioMed Central, 8 Apr. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5385025/.

Staff, Mayo Clinic. “Small Intestinal Bacterial Overgrowth (SIBO).” Mayo Clinic, Mayo Foundation for Medical Education and Research, 6 Jan. 2022, www.mayoclinic.org/diseases-conditions/small-intestinal-bacterial-overgrowth/diagnosis-treatment/drc-20370172.

Takakura, Will, and Mark Pimental. “Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – an Update.” Frontiers in Psychiatry, U.S. National Library of Medicine, 10 July 2020, pubmed.ncbi.nlm.nih.gov/32754068/.

Disclaimer

An Understanding Of SIBO & SIFO | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

Inside the body, the gut and the intestines make sure that everything is working properly. The gut and intestinal system make sure that the consumed food is being digested and the nutrients from the food are being transported all over the entire body. The gut system makes sure that the body is being supported by regulating the growth, metabolism, and immune support of all the organ systems and that each of the systems is doing its job. When harmful pathogens enter the body and start to disrupt the gut system, it can lead to chronic gut disorders over time if it is not treated right away. In this 2 part series, we will be taking a look at how SIBO and SIFO affect the gut as well as their symptoms. In Part 2, we will be taking a look at different treatments for SIBO and SIFO to optimize gut health. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Is SIBO?

SIBO, or small intestinal bacterial overgrowth, is a condition where an abnormally large number of bacteria (at least 10,000 bacteria per ml of duodenal aspirate) are present in the small intestines. In the small intestines, as research shows, when the food is being digested, gastric acids and biles are being destroyed. The bacteria are being prevented from entering through the intestines, providing optimal function. When there is an abundance of excessive bacteria in the small intestines causing problems, this is known as SIBO. SIBO is a commonly known gastrointestinal disorder that affects millions of individuals. Other research studies have shown that the common risk factors for SIBO include disturbances in the small bowel anatomy and motility in the gut system. The gut system needs the intestines to regulate the good bacteria for the stomach and the other organs to be functional. When SIBO starts to cause the bacterial growth to be excessive, it can cause many gut disorders to pop up and cause many disturbances to the gut and the body.

The Symptoms

The human body requires the balance of beneficial flora in the gut to maintain optimal function of the body through a complex series of chemical and mechanical operations. Research studies show that it is normal to have bacteria living in the intestines. Still, when there is an overabundance of bacteria growing in the intestines, the harmful bacteria can overtake and overwhelm the good bacteria, causing an upset to the digestive system. The harmful bacteria will begin to feed on the consumed food products meant for the good bacteria. Some of the symptoms that are from SIBO include:

Abdominal pain
Nausea
Bloating
Indigestion
Constipation
Unintentional weight loss
Fatigue

How SIBO Affects The Gut

Small Intestinal Bacterial Overgrowth(SIBO) Steals Your Nutrients – Dr.Berg

The small intestines in the gut system ensure that the nutrients and the food mixed with digestive juices are being absorbed into the bloodstream and transported throughout the entire body. When SIBO is developing in the small intestines, research studies have shown that stagnant food in the small intestines is an ideal breeding ground for harmful bacteria to produce toxins and interfere with the absorbed nutrients. SIBO can steal the nutrients from the consumed, digested food. If it is not treated right away, the harmful bacteria will begin to overproduce and take over the beneficial bacteria. This will cause many gut issues and disorders to the gut system causing the body to be dysfunctional.

What Is SIFO?

When there is an abundance of fungal growth in the intestines can lead to many disorders in the gut, just like SIBO. SIFO or small intestinal fungal overgrowth is a condition where abnormally large numbers of fungi/yeast are found in the small bowel that is associated with gastrointestinal (GI) symptoms, as research studies have stated. SIFO is generally defined as greater than 1,000 fungi per ml of small intestinal aspirate that can also occur in the large intestine. This is known as LIFO (large intestinal fungal overgrowth. SIFO and LIFO are commonly used together in clinical settings since it is difficult to ascertain where the overgrowth is. Other research studies have stated that SIFO is usually part of immunodeficiency syndrome with other GI disorders.

The Symptoms

Research studies have found that SIFO can often develop in individuals with either a weakened immune system or a healthy immune system. The Candida species are located in the mouth, the skin, and the intestines. At low levels, it shouldn’t cause any problems in the body or the gut system; however, if it is not being checked, the fungal species will begin to grow uncontrollably, causing various infections in and out of the body. Some of the symptoms that are caused by SIFO are similar to SIBO as they can cause:

Crohn’s disease
Ulcerative colitis
Abdominal bloating
Gas
Diarrhea
Abdominal pain

Conclusion

The gut system needs beneficial bacteria in the intestines to help digest and absorb nutrients into the bloodstream to be transported throughout the entire body. These beneficial bacteria help maintain the body’s growth, metabolism, and immune support, making it function properly. When harmful pathogens enter the gut system and cause an overabundance of harmful bacteria in the intestines, it can cause the development of both SIBO and SIFO. These gastrointestinal disorders can disrupt the gut system and cause dysfunction in the entire body if it is not treated right away. Incorporating gut-healthy therapies can provide relief to not only the gut but also the body.

References

Erdogan, Askin, and Satish S C Rao. “Small Intestinal Fungal Overgrowth.” Current Gastroenterology Reports, U.S. National Library of Medicine, Apr. 2015, pubmed.ncbi.nlm.nih.gov/25786900/.

Medical Professionals, Cleveland Clinic. “SIBO (Small Intestinal Bacterial Overgrowth): Symptoms, Diet, Causes & What It Is.” Cleveland Clinic, 1 Oct. 2021, my.clevelandclinic.org/health/diseases/21820-small-intestinal-bacterial-overgrowth-sibo.

Seladi-Schulman, Jill. “SIFO: Small Intestinal Fungal Overgrowth and Your Gut Health.” Healthline, Healthline Media, 4 Dec. 2019, www.healthline.com/health/sifo#what-is-sifo.

Singh, Rajdeep, and Gerard E Mullin. “A Wasting Syndrome and Malnutrition Caused by Small Intestine Fungal Overgrowth: Case Report and Review of the Literature.” Integrative Medicine (Encinitas, Calif.), InnoVision Health Media Inc., June 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6419785/.

Sorathia, Sufian J., et al. “Small Intestinal Bacterial Overgrowth.” StatPearls [Internet]., U.S. National Library of Medicine, 31 Jan. 2022, www.ncbi.nlm.nih.gov/books/NBK546634/.

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GERD & The Role Of Stomach Acid

Dr. Alex Jimenez

Table of Contents

Introduction

The gut system makes sure that any food that is being digested gets turned into nutrient particles and is transported all over the entire body. The food particles will be secreted out of the body to prevent waste from building up in the gut. The primary function of the gut system is to make sure that any food is being transformed into nutrients to help with growth, metabolism, and immune support for a functional body. The gut system also has a bidirectional connection to the brain as they send information back and forth to each other and keep the organs from being dysfunctional. When harmful pathogens enter the gut system, they can develop into chronic issues and affect the gut and the body. In this article, we will be looking at what GERD is, its symptoms, and how it can affect stomach acid. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Is GERD?

Research studies have shown that GERD usually occurs when stomach acid frequently flows back and forth in the tube, where the mouth and the esophagus are connected, irritating the esophagus wall lining. So GERD or gastroesophageal reflux disease is the reflux of gastric contents into the esophagus in normal physiology and is defined as reflux leading to symptoms, esophageal mucosal injury, or both. The majority of individuals with GERD will show no abnormalities on upper endoscopy, and there are not any esophageal lesions (erosions, ulceration, intestinal metaplasia) for them to be diagnosed with GERD. Other research studies have also shown that GERD is a common digestive disorder that affects people worldwide and has troublesome symptoms and conditions that can affect a person’s quality of life.

The Symptoms Of GERD

Some of the typical symptoms of GERD that individuals will experience are heartburn, which is painful retrosternal burning or pressure sensation that may be angina‐like in quality, and regurgitation, which is the rising of gastric contents into the upper throat or mouth. Studies have shown that GERD can also be defined as mucosal damage due to the production of abnormal reflux of gastric contents. GERD can also be classified as NERD (non-erosive reflux disease) or ERD (erosive reflux disease) depending on how severe the presence or absence of esophageal mucosal damage GERD has caused in the esophagus. Some of the other symptoms that GERD can cause to the gut system and the body include:

Hoarseness
Cough
Asthma
Pharyngitis
Erosion of dental enamel
Sinusitis
Pulmonary fibrosis
Tonsillar hypertrophy
Recurrent otitis media
Sleep disturbances or apnea

An Overview Of GERD

When a person gets acid reflux or even heartburn, it is completely normal since it does happen to anyone at some point in their lives. However, they develop GERD when they experience these gastric symptoms more than twice a week. GERD, as research shows, is a condition where stomach acid flows back and forth, irritating the esophageal tube. This is due to the esophageal sphincter not closing correctly as the food enters the stomach and the acid backwash leaves a sour taste in the throat and mouth.

GERD & The Role Of Stomach Acid

The stomach acid in the gut system ensures that the consumed food is digested and transported to the intestines (both large and small) to be distributed to the body, making it function properly. Research studies have found that weak stomach acid and bile in the stomach can cause unwanted gut disorders like GERD, esophagitis, and Barrett’s esophagitis. When GERD is disrupting the stomach acids by forcing them to go back and forth in the esophageal tube, it can cause unwanted symptoms that can cause a person discomfort. Weak stomach acid can also trigger persistent symptoms causing it to be the key to reflux symptoms in the gut.

GERD & Asthma

There are about 25 million individuals that have asthma, and this disorder can affect how a person breathes. However, GERD can trigger asthma symptoms by affecting the vagal reflex, the presence of acid in the esophagus, and the microaspiration of gastric contents into the trachea. Research studies have found that asthma and GERD can often occur together as GERD can worsen asthma symptoms. Conversely, asthma may cause GERD by altering the intrathoracic pressure, triggering the vagal reflex.

Other research studies have found that asthma causes chronic inflammation of the airways. When GERD interacts with asthma, it can cause an effect on the airways with an aspiration-induced response or even cause neurogenically induced inflammation. Since GERD is common for individuals with asthma, the symptoms and triggers can be developed into chronic issues over time. Studies have found that the installation of acid to reflux in the esophagus can stimulate vagal time and may trigger asthma symptoms in the airways.

Dilated Intercellular Spaces (DIS)

DIS or dilated intercellular spaces are also known as “leaky esophagus syndrome” as they are present on esophageal biopsy in virtually all GERD patients. Research studies have shown that DIS is considered a marker for GERD as the epithelial barrier is being reflected as an increase in paracellular permeability. The pathophysiology for DIS is thought to be repeated mucosal exposure to:

Refluxed acid
Digestive enzymes
Bile acids

Dilated intercellular spaces may be responsible for the enhanced perception of proximal acid reflux and the symptoms in NERD individuals irrespective of esophageal acid exposure. Other research studies have shown that even though DIS is a structural marker of GERD symptoms, it does play a vital role in the pathophysiology of NERD individuals. DIS is also present in about 30% of asymptomatic patients with esophageal candidiasis, food allergies, eosinophilic esophagitis, and esophageal cancer.

Conclusion

Therefore, the gut system needs acid in the stomach as it helps break down the food into particles and be digested in the intestines, where it is transported throughout the entire body. When gut issues like GERD start to affect the wall linings of the esophagus, it can cause acid reflux and other symptoms to cause the gut to be upset. Suppose the symptoms are not treated right away. It can cause other chronic issues to flare up, like asthma symptoms and other gut disorders, developing over time, causing the body to be dysfunctional. Treatments for gut issues that are anti-inflammatory can provide relief to gut inflammation. They can even dampen the effects of inflammation not just in the gut but also in the entire body.

References

Ates, Fehmi, and Michael F Vaezi. “Insight into the Relationship between Gastroesophageal Reflux Disease and Asthma.” Gastroenterology & Hepatology, Millennium Medical Publishing, Nov. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC5395714/.

Badillo, Raul, and Dawn Francis. “Diagnosis and Treatment of Gastroesophageal Reflux Disease.” World Journal of Gastrointestinal Pharmacology and Therapeutics, Baishideng Publishing Group Inc, 6 Aug. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4133436/.

Caviglia, Renato, et al. “Dilated Intercellular Spaces of Esophageal Epithelium in Nonerosive Reflux Disease Patients with Physiological Esophageal Acid Exposure.” The American Journal of Gastroenterology, U.S. National Library of Medicine, Mar. 2005, pubmed.ncbi.nlm.nih.gov/15743349.

Clarrett, Danisa M, and Christine Hachem. “Gastroesophageal Reflux Disease (GERD).” Missouri Medicine, Journal of the Missouri State Medical Association, 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6140167/.

Li, James T C. “Asthma and Acid Reflux: Are They Linked?” Mayo Clinic, Mayo Foundation for Medical Education and Research, 30 Mar. 2021, www.mayoclinic.org/diseases-conditions/asthma/expert-answers/asthma-and-acid-reflux/faq-20057993.

Mastronarde, John G. “Is There a Relationship between Gerd and Asthma?” Gastroenterology & Hepatology, Millennium Medical Publishing, June 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3424477/.

Medical Professionals, Cleveland Clinic. “Gerd (Chronic Acid Reflux): Symptoms, Treatment, & Causes.” Cleveland Clinic, 6 Dec. 2019, my.clevelandclinic.org/health/diseases/17019-gerd-or-acid-reflux-or-heartburn-overview.

Orlando, Lori A, and Roy C Orlando. “Dilated Intercellular Spaces as a Marker of Gerd.” Current Gastroenterology Reports, U.S. National Library of Medicine, June 2009, pubmed.ncbi.nlm.nih.gov/19463218/.

Richter, Joel E. “Role of the Gastric Refluxate in Gastroesophageal Reflux Disease: Acid, Weak Acid and Bile.” The American Journal of the Medical Sciences, U.S. National Library of Medicine, Aug. 2009, pubmed.ncbi.nlm.nih.gov/19590427/.

Staff, Mayo Clinic. “Gastroesophageal Reflux Disease (GERD).” Mayo Clinic, Mayo Foundation for Medical Education and Research, 22 May 2020, www.mayoclinic.org/diseases-conditions/gerd/symptoms-causes/syc-20361940.

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How Sterolbiome & Bile Reflux Affect The Gut | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

The body requires the gut and the intestines (both small and large) to store, digest, and transport the nutrients from food to all the body’s organs, tissues, muscles, and cells. These nutrients help the body by keeping it functional and promoting growth, metabolism, and immune support. When the food is being digested, the liver sends out bile acids to aid in the digestion process to break food particles and transport them and secreting them out of the body. Sometimes specific gut issues can start to affect both the intestines and gut, causing discomfort to the body. In this 2 part series, we will be looking at how bile acids are hormones, sterolbiome, and bile reflux. Part 1 looks at what bile acids are, their role in the gut, and what gall sludge is. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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Are Bile Acids Hormones?

Research studies have found that the bile salts from bile acids are considered nutrient signaling hormones. They play a crucial role by allowing the gastrointestinal system to digest, transport, and metabolize nutrients throughout the entire body. Bile acids are hormones that regulate:

Their synthesis and transport
Glucose and lipid homeostasis
Energy balance
Inflammation
Microbial growth

Other research studies have found that the essential role of bile acids is that they act as regulators for energy metabolism by acting as emulsifiers to cholesterol in the intestines. They can act like typical steroid hormones by having specific intracellular receptors in the target cells. When bile acids are in the intestines, they ensure that the particles are broken down and secreted into the bloodstream.

Sterolbiome

The gut microbiome or sterolbiome produces endocrine molecules from cholesterol-based molecules in the gut known as bile acids. Bile acids are also known to shape the gut microbiome fundamentally and vice versa, as studies show that bile acids can facilitate fat absorption while playing a role in glucose and metabolism regulation. This is important for bile acids mechanics because it can help stimulate the secretion of gut hormones. Other bacteria in the gut known as Clostridium scindens can help both the male and female bodies. This bacteria can increase blood estrogen levels and convert cortisol to male sex hormones while deconjugating the estrogen, allowing the hormone to be absorbed from the gut, advancing a more active serum estrogen.

Other studies have found that when bile acids are returned to the liver after circulating throughout the intestines and the body and accumulating in the biliary pool, the gut microbial community will produce bile acid metabolites through their capacity from the liver as an endocrine hormone.

How Bile Reflux Affect The Gut

When bile acids are abundant in the gastrointestinal tract, it can cause a backup to the stomach organ and cause damage to the wall linings to the stomach and esophagus. It can cause tissue damage and inflammation in the gut system when this happens. If left untreated, it can turn into GERD or SIBO, causing more gut inflammation and making a person’s life miserable. However, there are some ways to dampen the effects of bile reflux by utilizing anti-inflammatory therapy treatments.

What Is GERD?

When the role of bile acids is a cause of esophageal inflammation or Barrett’s esophagus, a condition in which the esophageal lining cells become transformed (pre-cancerous). This is known as GERD or gastroesophageal reflux disease. Research studies have shown that GERD usually occurs when stomach acid frequently flows back and forth into the tube that connects the mouth and stomach, which can irritate the esophagus lining. So bile acids will be exclusively in conjugated form unless there is abnormal bacterial deconjugation in the duodenum.

There is little reflux of duodenal fluid into the stomach or esophagus in a healthy person because intragastric pressure is higher than intraduodenal pressure. However, in individuals with disordered gastroduodenal motility or pyloric sphincter dysfunction, there may be duodenal reflux that leads to reflux from the stomach to the esophagus. Other research studies show that now and then, mostly everyone has acid reflux and heartburn, which is entirely normal. However, if a person has acid reflux or heartburn more than twice a week, they are developing GERD in their gut system.

Bile Reflux

Reflux of duodenal contents through the pyloric valve is purported to be more common after cholecystectomy but is also seen in individuals with an intact gall bladder. Bile reflux, as research shows, can occur when the bile acids are backed up in the stomach and can be accompanied by stomach acid reflux into the esophagus. There are many ways this can happen to the gut as bile acids are produced in the liver, and their job is to break down food into particles. Other research studies have shown that when the valves in the digestive tract are not functioning right, bile reflux can happen and flow right back into the organs where they don’t belong.

Conclusion

Since the liver is the one to produce bile acids, it is known as a nutrient signaling hormone that is essential for gut metabolism, energy balance, and homeostasis to glucose and lipids. All in all, bile acids are part of the digestive system as they help break down foods into particles and help them be transported throughout the entire body. When there is little bile fluid in the intestines, it can cause gut disorders like GERD or bile reflux, causing the bile acid to go into the stomach and causing irritation to the wall linings esophagus, causing discomfort to the individual. Incorporating anti-inflammatory treatments into the gut system can help the bile acids return to normal and make the body functional.

References

Kuhre, Rune E, et al. “Bile Acids Are Important Direct and Indirect Regulators of the Secretion of Appetite- and Metabolism-Regulating Hormones from the Gut and Pancreas.” Molecular Metabolism, Elsevier, May 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6001409/.

Medical Professionals, Cleveland Clinic. “Bile Reflux: Symptoms, Treatment, Causes & What It Is.” Cleveland Clinic, 18 Nov. 2021, my.clevelandclinic.org/health/diseases/22056-bile-reflux.

Ridlon, Jason M, and Jasmohan S Bajaj. “The Human Gut Sterolbiome: Bile Acid-Microbiome Endocrine Aspects and Therapeutics.” Acta Pharmaceutica Sinica. B, U.S. National Library of Medicine, 9 Feb. 2015, pubmed.ncbi.nlm.nih.gov/26579434/.

Staff, Mayo Clinic. “Bile Reflux.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 6 Jan. 2022, www.mayoclinic.org/diseases-conditions/bile-reflux/symptoms-causes/syc-20370115.

Zagoskin, P P, and E I Erlykina. “Bile Acids as a New Type of Steroid Hormones Regulating Nonspecific Energy Expenditure of the Body (Review).” Sovremennye Tekhnologii v Meditsine, Privolzhsky Research Medical University, 28 Oct. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC8596256/.

Zhou, Huiping, and Phillip B Hylemon. “Bile Acids Are Nutrient Signaling Hormones.” Steroids, U.S. National Library of Medicine, Aug. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4073476/.

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How Bile Acids Help Regulate The Gut | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

The body’s primary job is to make sure that each organ system works correctly and does its job. One of the systems in the body is the gut system, and its position is to make sure that the food is being consumed and digested to be turned into nutrients and transported throughout the entire body. The gut system makes sure that the food is being digested and excreted out of the body to be functional. The digestion of the food being turned into particles is done through the bile acids in the stomach and the intestines (both large and small) to help turn the foods into nutrients and help regulate the entire digestive system. In this 2 part series, we will be looking at what bile acids are, their role in the gut, and what gall sludge is. Part 2 will look at how bile acids are hormones, sterolbiome, and bile reflux. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

The Gut’s Role In The Body

Since the human body is a complex ecosystem that is predominantly bacterial on a cellular and gene level, the various surfaces of the body are an interconnected network of ecosystems made up of human cells, bacteria, and archaea. These include:

Skin
Oral
Gastrointestinal
Respiratory
Reproductive tract

As research studies have found, the gut microbiota is home to a complex community of over trillions of microbial cells that help influence the human body’s physiology, metabolism, nutrition, and immune function to ensure that everything is working and functioning correctly. Through their capacity, the gut microbial community can also produce bile acid metabolites that are distinct from the liver. The produced bile acids from the liver can be thought of as an endocrine organ with the potential to alter host physiology, perhaps to their favor.

Bile Acids

Bile acids are produced from the liver to help with the aid of digestion of foods to be absorbed into the body. The liver synthesizes and secretes water-soluble primary bile acids, converted by intestinal flora into numerous fat-soluble compounds. Research studies show that bile acids are large molecules synthesized from cholesterol in the liver and are secreted out to the intestines. After that, these bile acids are absorbed into the blood, returned to the liver, and accumulate in the biliary pool. It takes about 16 enzymes needed to convert cholesterol to bile acids.

Other research studies have also found that the composition of the bile pool is being mediated by the bacterial metabolism in the intestinal tract, thus linking to the body’s physiology. When this happens, the liver cells also attach bile salts to glycine, taurine, sulfate, or glucuronide, forming a conjugation. However, flora in the ileum and colon may undo this process, causing a deconjugation as Bilirubin pigments are conjugated with glucuronic acid. Gilbert’s syndrome occurs if this does not happen as well as it should due to a genetic enzyme deficiency. For the bile pool, the primary mechanism for removing cholesterol from the blood is excretion into the bile. About 5% of the bile gets into the large intestine and is eliminated in the stool. Although with increasing levels, these bile acids can cause diarrhea. It is hypothesized that if these bile acids are deficient, functional constipation may occur in the body.

Primary Bile Acids

Primary bile acids form micelles with lecithin and cholesterol to mix fat and water, allowing the absorption of fats and fat-soluble vitamins. Research studies have shown that the two primary bile acids are synthesized from cholesterol in the liver, which are:

Cholic acid
Chenodeoxycholic acid

The primary bile acid chenodeoxycholic acid (CDCA) and the secondary bile acid deoxycholic acid (DCA) function as laxatives for the gastrointestinal tract. They do this by increasing water secretion from the blood into the bowel, causing the bile to be turned into a stool and being excreted out of the body. Primary bile acid also ensures that it is being secreted into the intestines, thus undergoing bacterial biotransformation that will generate the primary bile acid into secondary bile acid.

Secondary Bile Acids

Secondary bile acids are metabolites that influence nuclear receptors in the body as they can be carcinogens. The two secondary bile acids are made when intestinal flora act on the primary bile acids as:

Deoxycholic acid
Lithocholic acid

Since the biliary system is a route of detoxification for the liver, bile acids can be therapeutic agents for the body. Research studies have shown that the enterohepatic circulation of bile acids (both primary and secondary) from the liver to the intestines and back to the liver plays a vital role in nutrient absorption and distribution and provides metabolic regulation and homeostasis to the liver and the body.

An Overview Of Bile Acid In The Gut

Bile Pathways and the Enterohepatic Circulation, Animation

Bile acids are essential to the body’s overall health and wellness as they help break down food particles into nutrients so the body can use them for energy, growth, and metabolism. Studies have found that bile acids have been long known to facilitate digestion and absorption of lipids in the intestines and regulate cholesterol homeostasis. Since bile acids are produced from the liver, bile acids must regulate the endocrine and digestive systems for optimal health and wellness.

What Gallsludge Does To The Gut

Biliary sludge (microlithiasis) is a reversible suspension of precipitated particulate matter in bile in a viscous mucous liquid phase. The most common precipitates are cholesterol monohydrate crystals, calcium-based crystals, granules, and salts. Research studies have shown that gall sludge is when there is a collection of particles from the bile acids that are remaining in the gallbladder for too long. Individuals with biliary sludge or microlithiasis are believed to be gallstone patients at an early stage of their disease. The best way for many individuals to treat gall sludge is to go for oral bile-acid therapy. This therapy is for mildly symptomatic individuals with small radiolucent stones who cannot or do not want to undergo surgery. Other research studies have found that medical treatment can help prevent sludge formation and recurrent acute pancreatitis.

Conclusion

Overall, the gut system needs bile acids to aid in the progress of digestion and absorb the nutrients from food particles in the stomach. The food particles then go through biotransformation as they are broken down further from the primary bile acids and then transformed to become secondary bile acids. Since the bile acids are produced from the liver, it is considered a hormone with an essential function by ensuring that the entire body functions correctly and excreting out. When the bile acids have stayed in the gallbladder for long periods, it can create gall sludge and cause unwanted diseases in the body. Incorporating proper gut health protocols can provide beneficial results in producing bile acids and ensuring a healthy body.

References

National Institute of Diabetes and Digestive and Kidney Diseases; 2012-., Bethesda (MD). “Bile Acids.” LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]., U.S. National Library of Medicine, 25 Sept. 2017, www.ncbi.nlm.nih.gov/books/NBK548626/.

Chiang, John Y L. “Bile Acid Metabolism and Signaling.” Comprehensive Physiology, U.S. National Library of Medicine, July 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC4422175/.

Guinane, Caitriona M, and Paul D Cotter. “Role of the Gut Microbiota in Health and Chronic Gastrointestinal Disease: Understanding a Hidden Metabolic Organ.” Therapeutic Advances in Gastroenterology, SAGE Publications, July 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3667473/.

Jain, Rajeev. “Biliary Sludge: When Should It Not Be Ignored?” Current Treatment Options in Gastroenterology, U.S. National Library of Medicine, Apr. 2004, pubmed.ncbi.nlm.nih.gov/15010024/.

Staels, Bart, and Vivian A Fonseca. “Bile Acids and Metabolic Regulation: Mechanisms and Clinical Responses to Bile Acid Sequestration.” Diabetes Care, American Diabetes Association, Nov. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2811459/.

Staley, Christopher, et al. “Interaction of Gut Microbiota with Bile Acid Metabolism and Its Influence on Disease States.” Applied Microbiology and Biotechnology, U.S. National Library of Medicine, Jan. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5203956/.

Taylor, Sarah A, and Richard M Green. “Bile Acids, Microbiota, and Metabolism.” Hepatology (Baltimore, Md.), U.S. National Library of Medicine, Oct. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6173626/.

Villines, Zawn. “Gallbladder Sludge: Symptoms, Causes, and Treatments.” Medical News Today, MediLexicon International, 18 Nov. 2017, www.medicalnewstoday.com/articles/320057.

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Therapeutic Ways To Treat Inflammatory Bowel Disease | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

The gut system is where food is being consumed and digested in the gastrointestinal (GI) tract and excreted out of the body. The acids and gastric juices from the gut turn the food into particles where the nutrients and vitamins are being transferred throughout the entire body while ensuring that each of the central systems is working correctly. From the immune system, central nervous system, the endocrine system to the muscle tissues and the cellular structure needs the gut as it helps regulate the functions that the body goes through. When disruptors start to attack the stomach, it can cause inflammatory symptoms like IBD, Crohn’s disease, or ulcerative colitis to cause havoc to the intestinal permeability causing the individual to be in constant pain. In this 2 part series, we will be looking at how IBD affects the other organs and what kind of treatments can dampen IBD symptoms. Part 1 looked at the pathophysiology of IBD (inflammatory bowel disease) and how its symptoms affect the gut system. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

How IBD Affects The Other Organs

Part 1 showed the pathophysiology of IBD or inflammatory bowel disease and how it affects the gut system. IBD is a progressive chronic inflammatory disease that can spread all over the small and large intestines. Studies have found that IBD results from the interaction between both genetic and environmental factors that can influence the body’s immune response. IBD does split off into two chronic diseases: ulcerative colitis and Crohn’s disease, even though they have the same symptoms like causing digestive disorders and inflammation in the intestines. When inflammation is in its chronic state, it can cause anybody to be in constant pain in the body. This is due to various factors that have entered the body and attached themselves to the gut permeability, causing the immune system to attack the permeability wall causing toxins and bacteria to leak out, and causing more problems to the body. Other research studies have found that IBD can affect the other organs in the body as IBD is frequently associated with the development of extraintestinal manifestations. Extraintestinal manifestations are common in IBD that involve almost all the organ systems in the body, causing them to contribute to morbidity in many individuals with IBD.

An Overview Of Inflammatory Bowel Disease

Inflammatory bowel disease: triggers, diet tips and treatment

IBD or inflammatory bowel disease is a chronic inflammatory disease that affects the digestive system’s gut and intestines. The signs and symptoms of an individual with IBD will vary on how severe it is. The symptoms can range from mild to severe. They can spread out all over the small and large intestines causing chronic inflammation to affect the intestinal walls and causing individual pain either gradually or suddenly, depending on the severity of the symptoms. There are treatments for IBD to dampen the chronic inflammatory effects in the intestines and provide relief to those who have IBD.

Treatments For IBD

Research studies have found that the goal to treat IBD is to reduce inflammation that triggers the IBD signs and symptoms in the body. By incorporating anti-inflammatory treatments into the body, anybody dealing with IBD will have relief from the inflammatory symptoms, have a long-term remission, and have a reduced risk of complications from popping up in the future. Other research studies have shown that even though there is no cure for IBD at the moment, reducing the symptoms, achieving and maintaining remission, and preventing complications can lower inflammation from IBD and even provide relief to other chronic issues that are causing the body pain. Some of the treatments to decrease IBD inflammation can include:

Lifestyle changes
Anti-inflammatory diet
Reducing stress
Avoid smoking
Exercise
Meditation

Curcumin & IBD

Curcumin is a yellow-colored root that is the primary substance in turmeric that has exceptional anti-inflammatory properties that can dampen the effects of IBD inflammation. Research studies have shown that even though IBD is a chronic relapsing-remitting condition, it is driven by inflammatory cytokines. When individuals take curcumin, its antioxidant effects can dampen it. Since inflammatory cytokines are driving IBD, the NF-kappaB receptor is a critical factor in upregulating these cytokines, which causes a high profile in inflammatory diseases. Other research studies have shown that certain natural products like curcumin provide anti-inflammatory properties that can help lower the inflammation involved with intestinal inflammatory diseases. Curcumin can help the digestive system by improving the intestinal barrier function from IBD. Its antimicrobial and immunomodulatory properties can potentially alter the intestinal microbiome back to its original function.

Omega-3s & IBD

Research studies have found that incorporating omega-3 in a diet can help lower the inflammatory effects of IBD in the body. Omega-3 polyunsaturated fatty acids have anti-inflammatory properties that can resolve the inflammation process of IBD by reducing oxidative stress, decreasing the expression of adhesion molecules, and can work as a chemopreventive agent in the body. Other research studies have shown that when individuals suffering from IBD or ulcerative colitis take omega-3s daily as part of their diet, it will reduce intestinal inflammation and induce and maintain clinical remission. Omega-3s have beneficial effects when lowering inflammation in the body since they can also reduce proinflammatory cytokines that trigger IBD symptoms. Many individuals taking omega-3s daily will be able to prevent and treat IBD symptoms from coming back again.

Conclusion

All in all, IBD is a chronic inflammatory disease that causes inflammatory symptoms to the gut and the intestines to be in pain. Since the gut system provides nutrients and minerals from digested food, the body and other organ systems need these nutrients to ensure that the body is functioning correctly. When chronic diseases like IBD affect the gut and the intestines, the individual will begin to feel the pain coming from their gut, and if it is not treated right away, it can become life-threatening. Utilizing anti-inflammatory treatments like incorporating curcumin and omega-3s into their diet can help lower inflammation in the gut. Incorporating anti-inflammatory foods, exercising, and changing lifestyle habits can benefit many individuals on their wellness journey and become pain-free without worrying about chronic inflammation.

References

Barbalho, Sandra Maria, et al. “Inflammatory Bowel Disease: Can Omega-3 Fatty Acids Really Help?” Annals of Gastroenterology, Hellenic Society of Gastroenterology, 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4700845/.

Burge, Kathryn, et al. “Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection.” International Journal of Molecular Sciences, MDPI, 18 Apr. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6514688/.

Chams, Sana, et al. “Inflammatory Bowel Disease: Looking beyond the Tract.” International Journal of Immunopathology and Pharmacology, SAGE Publications, 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6685113/.

Hanai, Hiroyuki, and Ken Sugimoto. “Curcumin Has Bright Prospects for the Treatment of Inflammatory Bowel Disease.” Current Pharmaceutical Design, U.S. National Library of Medicine, 2009, pubmed.ncbi.nlm.nih.gov/19519446/.

Leonard, Jayne. “Inflammatory Bowel Disease: Causes, Symptoms, and Treatments.” Medical News Today, MediLexicon International, 13 Apr. 2020, www.medicalnewstoday.com/articles/316395.

Marton, Ledyane Taynara, et al. “Omega Fatty Acids and Inflammatory Bowel Diseases: An Overview.” International Journal of Molecular Sciences, MDPI, 30 Sept. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6801729/.

Seyedian, Seyed Saeid, et al. “A Review of the Diagnosis, Prevention, and Treatment Methods of Inflammatory Bowel Disease.” Journal of Medicine and Life, Carol Davila University Press, 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6685307/.

Staff, Mayo Clinic. “Inflammatory Bowel Disease (IBD).” Mayo Clinic, Mayo Foundation for Medical Education and Research, 7 Nov. 2020, www.mayoclinic.org/diseases-conditions/inflammatory-bowel-disease/diagnosis-treatment/drc-20353320.

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The Pathophysiology Of Inflammatory Bowel Disease | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

In the body, the digestive system makes sure that the food that is being consumed is digested in the gastrointestinal (GI) tract and the nutrients, minerals, and vitamins are being transported all throughout the entire body. Once that is done, the excess unused food is excreted out to avoid any issues that the gut or the body has encountered. Most of the time, the food a person eats can cause gut issues in the stomach and if a person continues to consume the same food, it can cause inflammation in the gut. When this happens, the inflammatory cytokines will attach themselves to the gut intestinal permeability and the immune system will begin to attack the intestinal permeability causing the toxins and gut bacteria to leak out and progress the gut inflammation further turning into IBD (inflammatory bowel disease). In this 2 part series, we will be taking a look at the pathophysiology of IBD (inflammatory bowel disease) and how its symptoms affect the gut system. Part 2 will be taking a look at how IBD affects the other organs and what kind of therapeutic treatments can help dampen the symptoms of IBD. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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What Is IBD?

IBD or inflammatory bowel disease is when the digestive tract has chronic inflammation all over the digestive tract. When inflammation is in the body, it can be beneficial and harmful, depending on how severe it is. When inflammation is in its acute form, the immune system will send out the inflammatory cytokines to the injured area of the body, where it will attack the pathogen, causing the affected area to be red and hot to the touch for a few minutes to hours, depending on how severe it is. In its chronic state, however, inflammation can be caused either by a food allergen or sensitivity that can upset the gut system, an acute inflammation that hasn’t been treated, a person who has been exposed to toxins, or even an autoimmune disorder that can affect the body. When these factors start to cause the immune system to attack the healthy tissues like the gut permeability, it can lead to IBD. Research studies have shown that the exact cause of IBD is unknown, but factors can cause IBD to progress and aggravate the gut to develop IBD. Some of the risk factors that can exacerbate IBD are:

Age
Family history
Environmental triggers
Compromised immune system

Other research studies have found that IBD is defined as chronic intestinal inflammation of the small and large intestines causing the body’s immune system to attack the digestive system, thus encompassing two primary inflammatory forms known as Crohn’s disease and ulcerative colitis. When chronic inflammation in the gut, the epithelial cells are secreted out of the intestinal wall lining, causing the immune system to attack the intestines. This will lead to the development of Crohn’s disease and ulcerative colitis.

Crohn’s Disease

Research studies have shown that Crohn’s disease is a type of IBD that causes inflammation in different areas of the digestive tract in other individuals. This chronic inflammation can often spread into deeper layers of the intestinal bowels. It can be painful, leading to life-threatening situations for some individuals with Crohn’s disease. The pathophysiology of Crohn’s disease is due to how it is multifactorial as studies have found that Crohn’s disease has the characteristics of transmural inflammation that affects the entire GI tract causing granuloma formation. What this does is that granuloma formation from Crohn’s disease causes ongoing inflammation in the GI tract and scarring to the bowel structure. Other studies have shown that the factors for Crohn’s disease can include a person’s age, family history, environmental factors, and other chronic disorders that can cause Crohn’s disease to progress further in the body, causing the individual to be in constant pain.

Ulcerative Colitis

Ulcerative colitis is another form of IBD that is an idiopathic inflammatory condition that causes diffuse friability and superficial erosion of the colonic walls and can cause the colon to bleed, as studies show. What ulcerative colitis does to the gut system is that it affects the large intestines or the colon by causing irritation and ulcers around the colon, making it very uncomfortable for individuals. Research studies show that ulcerative colitis causes inflammation of the rectum and can spread all over the colon, causing another form of ulcerative colitis known as ulcerative proctitis. The other conditions of ulcerative colitis are chronic as they affect the colon and can be severe depending on the location and the amount of inflammation is affecting the colon. Since the many forms of IBD can affect different people, the factors and symptoms can vary for each individual going from mild to severe if it is not treated.

The Pathophysiology Of IBD

Inflammatory Bowel Disease - Crohns and Ulcerative Colitits

The pathophysiology of IBD (inflammatory bowel disease) is where there is chronic inflammation around the gut, GI (gastrointestinal) tract, and both the large and small intestines. IBD also has two forms of inflammatory conditions known as Crohn’s disease and ulcerative colitis that can affect the intestines and the colon. The symptoms that these chronic inflammatory diseases also cause include abdominal pain, ulcers, diarrhea, and severe cramping, which can cause a person to be in constant pain. Since IBD, Crohn’s disease, and ulcerative colitis causes chronic inflammation of the digestive system, the factors that can cause these chronic diseases to progress can be due to genetics, compromised immune system, and environmental triggers.

The Symptoms Of IBD

Some of the symptoms that individuals with IBD (inflammatory bowel disease) can vary as they can come and go in the body. Research studies have found that individuals would experience mild or severe symptoms of IBD that can come gradually or suddenly at any time of day or night. Some of the symptoms that IBD causes include:

Abdominal pain
Bloating
Loss of appetite
Joint pain
Fatigue

IBD can also cause other symptoms because it can cause flare-ups in the gut and is common in about 3 million individuals affecting all ages and genders. It is different from IBS (irritable bowel syndrome) since IBS affects bowel function while IBD damages the intestines and increases the risk of colon cancer in many individuals.

Crohn’s Disease Symptoms

Research studies show that Crohn’s disease can affect any part of the small or large intestines and can cause unwanted issues to a person as it can affect the body. The signs and symptoms that a person with Crohn’s disease can vary from being mild to severe as they develop gradually or suddenly without any warning. The symptoms that Crohn’s disease can cause to a person include:

Abdominal pain
Fever
Weightloss
Anemia

Other symptoms that Crohn’s disease can cause in the body are extraintestinal manifestations. They can vary from a recurrence of urinary tract infections, arthritis, ankylosing spondylitis to a person having gallstones in their system.

Ulcerative Colitis Symptoms

Since ulcerative colitis affects the colon and the rectum, the signs and symptoms of ulcerative colitis can range from being mild to severe, as research shows. Unlike IBD and Crohn’s disease, ulcerative colitis’s symptoms develop over time and, depending on how the inflammation has progressed in the colon, can vary. Some of the signs that are caused by ulcerative colitis include:

Rectal pain
The inability to go to the bathroom
Nausea
Liver disease
Red, painful eyes
Mouth sores
Loss of fluids and nutrients

Conclusion

The gut system ensures that any food or liquid is being digested and excreted out of the body to ensure that everything is functioning correctly and that the nutrients are being transported throughout the entire body. Therefore, chronic inflammation in the gut system can cause IBD (inflammatory bowel disease) in the GI tract and cause many unwanted symptoms that can turn chronic over time if it is not treated right away. When chronic inflammatory diseases like IBD, Crohn’s disease, and ulcerative colitis affect the gut, many individuals will be in pain and try to find some relief to dampen the effects that it has caused in their gut system. The second part of this series will discuss how IBD affects the organs and how different treatments dampen the impact of IBD in the gut system.

References

Fakhoury, Marc, et al. “Inflammatory Bowel Disease: Clinical Aspects and Treatments.” Journal of Inflammation Research, Dove Medical Press, 23 June 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4106026/.

Ha, Francis, and Hanan Khalil. “Crohn’s Disease: A Clinical Update.” Therapeutic Advances in Gastroenterology, SAGE Publications, Nov. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4622286/.

Lynch, Whitney D., and Ronald Hsu. “Ulcerative Colitis.” StatPearls [Internet]., U.S. National Library of Medicine, 18 June 2021, www.ncbi.nlm.nih.gov/books/NBK459282/.

Medical Professionals, Cleveland Clinic. “Inflammatory Bowel Disease: Symptoms, Treatment & Diagnosis.” Cleveland Clinic, 3 May 2021, my.clevelandclinic.org/health/diseases/15587-inflammatory-bowel-disease-overview.

Medical Professionals, Cleveland Clinic. “Ulcerative Colitis: Symptoms, Treatment, Living with It & Diagnosis.” Cleveland Clinic, 23 Apr. 2020, my.clevelandclinic.org/health/diseases/10351-ulcerative-colitis.

Ranasinghe, Indika R., and Ronald Hsu. “Crohn Disease.” StatPearls [Internet]., U.S. National Library of Medicine, 8 June 2021, www.ncbi.nlm.nih.gov/books/NBK436021/.

Staff, Mayo Clinic. “Crohn’s Disease.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 13 Oct. 2020, www.mayoclinic.org/diseases-conditions/crohns-disease/symptoms-causes/syc-20353304.

Staff, Mayo Clinic. “Ulcerative Colitis.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 23 Feb. 2021, www.mayoclinic.org/diseases-conditions/ulcerative-colitis/symptoms-causes/syc-20353326.

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Complications Poor Posture

Dr. Alex Jimenez

Young woman in jeans bending over a copier. — Copy machine. Young woman in jeans and a green blouse bending over a copy machine, serious attentive.

As the body gets older, slouching, little to no physical activity, and regular stretching cause muscle fatigue, weakness, tension, leading to poor posture complications. The complications include:

Back and neck pain
Rounded shoulders
Spinal dysfunction
Joint degeneration
Sleep problems
Chronic pain

Posture can be improved along with overall spinal health and a better quality of life through chiropractic treatment. Chiropractic will improve posture through adjustments, postural exercise training and stretching, education on ergonomics, and nutrition to strengthen the body.

Table of Contents

Complications Poor Posture

Symptoms

Symptoms vary as they depend on the severity of the case and condition.

Muscle fatigue/weakness
Body aches and soreness
Back pain
Rounded shoulders
Standing and/or walking problems
Headaches
Potbelly

Mechanisms

Poor posture leads to dysfunction and interference with the body’s postural mechanisms. These include:

Slow-twitch and fast-twitch muscle fibers
Muscle strength and length
Body positioning nervous system feedback.

Muscle Fibers

Skeletal muscle comprises two types of muscle fiber. They are static or slow-twitch muscles and phasic or fast-twitch muscles. Static muscle fibers are found in the deeper muscle layers. Static fibers burn energy slowly and keep working without tiring. They help the body maintain posture without effort and contribute to balance by sensing the body’s position and transmitting the information to the brain. Phasic muscle fibers are used for movement and activity but can quickly run out of energy. Poor posture causes muscle fatigue because the phasic fibers are used rather than the static fibers to maintain the body’s proper position.

Muscle Strength and Length

Over time, the body constantly needs support from the phasic muscle fibers. This causes the deeper supporting muscles to waste away because they are not being used. Weak, unused muscles begin to tighten, causing a shortening of muscle length that can compact the spine’s bones and cause back complications.

Nervous System Feedback

The deeper layers of muscle sense the body’s position in space and relay this information to the brain. The brain does not receive complete transmission if the phasic muscle fibers take over this function. The brain assumes that the body needs to be propped up/corrected to counteract the poor posture effects, triggering further muscle contraction, adding to the fatigue and pain.

Listening To The Body

The objective is to form a habit of regularly listening to what the body is saying. Make minor adjustments while standing and sitting throughout the day/night. Often what happens is individuals become so immersed in their work, school tasks that they ignore any physical discomfort and push through and forget to change positions/move around to get the muscles moving and the blood pumping. If there is muscle tension or fatigue, don’t just work through the pain; move into another healthy position.

Posture Improvement

Suggestions include:

Try to avoid sitting in soft chairs.
Switch to ergonomic chairs for any activity that requires sitting for long periods.
Use a lumbar roll to support the lower back when sitting in regular chairs or driving.
Remember to reverse the curve; an example could be if leaning over a desk/workstation, stretch the back in the other direction.
Get into stretching exercises to increase muscle flexibility.
Strength train to improve muscle strength and tone.
Avoid standing for long periods.
Use a posture app.

Body Composition

Strength Training

As the body ages, it loses muscle mass, known as sarcopenia. Between the ages of 30 and 80, both men and women can lose 30-50 percent of their muscle strength. Decreasing strength can make it a challenge to lead an active lifestyle or have energy levels to complete the daily errands. Individuals can be reluctant to improve fitness levels through resistance workouts believing there is nothing left after years of inactivity. This is not true as anybody can strength train. With the right mindset, and health coaching team, goals can be set to:

Improve body composition
Improve energy levels
Maintain an active lifestyle

References

Creze, Maud et al. “Posture-related stiffness mapping of paraspinal muscles.” Journal of anatomy vol. 234,6 (2019): 787-799. doi:10.1111/joa.12978

Deliagina, Tatiana G et al. “Physiological and circuit mechanisms of postural control.” Current opinion in neurobiology vol. 22,4 (2012): 646-52. doi:10.1016/j.conb.2012.03.002

Korakakis, Vasileios et al. “Physiotherapist perceptions of optimal sitting and standing posture.” Musculoskeletal Science & practice vol. 39 (2019): 24-31. doi:10.1016/j.msksp.2018.11.004

Pollock, A S et al. “What is balance?.” Clinical rehabilitation vol. 14,4 (2000): 402-6. doi:10.1191/0269215500cr342oa

Waters, Thomas R, and Robert B Dick. “Evidence of health risks associated with prolonged standing at work and intervention effectiveness.” Rehabilitation nursing: the official journal of the Association of Rehabilitation Nurses vol. 40,3 (2015): 148-65. doi:10.1002/rnj.166

How Gut Disorders Affect The GI Motility | Part 2

Dr. Alex Jimenez

Table of Contents

Introduction

Part of the digestive system’s primary system is to make sure that the food that a person is consuming is being digested and excreted out. The digested food is packed with vitamins and nutrients that the immune system, muscle tissues, cells, organs, and the body needs to function correctly. When unwanted pathogens or disruptors enter the body and travel through the gut system, it can cause chronic issues to develop and cause harm to each of the systems. However, many treatments can help both the body and the gut system dampen the effects and make the body feel better. In this 2 part series, we will be looking at how gastrointestinal disorders can affect the gut and what kind of treatments dampen their effects. Part 1 looked at the GI tract and how each organ functions in the digestive system, and how the enteric nervous system and each muscle cells work together. By referring patients to qualified and skilled providers who specialize in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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Disorders Of GI Motility

When pathogens start to enter the body and affect the gut system, many problems will affect the gut and the body itself. These are known as gastrointestinal motility disorders. Research shows that gastrointestinal motility disorders have many signs and symptoms that can occur anywhere throughout the luminal gastrointestinal tract. Some of these disorders can affect:

Gastric motility
Small intestinal motility
Colon and anorectal motility

These disorders can cause many gut issues and diseases like SIBO, gastroparesis, constipation, diarrhea, and IBS (irritable bowel syndrome) to make a person feel miserable and cause pain if not treated. Other research studies have found that gastrointestinal dysmotility can also cause a delay in gastric emptying and cause obstruction in the large and small intestines. When this happens, the consumed food will not be able to pass through the intestines, and the intestinal muscles will have contractions causing the individual to be in pain.

Gastroparesis

Gastroparesis is derived from the Greek words “gastro” and “paresis,” which means partial paralysis of the stomach. Research studies have shown that gastroparesis is a condition of collective symptoms like bloating due to nausea and vomiting that causes delayed emptying of the stomach in the absence of mechanical obstruction. Some of the most common signs that are caused by gastroparesis include:

Nausea
Abdominal pain
Early satiety
Vomiting

The symptoms can vary from intermittent to severe, depending on how sour the stomach is. In a normal gut function, the proximal stomach will expand to accommodate the food consumed, and the intragastric pressure is maintained. The food solids are broken down into 1-2 mm particles with contractions causing the gastric emptying to be 50% in 2 hours and 90% in 4 hours. With gastroparesis, the stomach will lose all of the accommodations and alter the antral phasic contractions causing the stomach to be in visceral hypersensitivity.

Irritable Bowel Syndrome

Irritable bowel syndrome or IBS is a functional bowel disorder that causes chronic or recurrent abdominal pain or discomfort in the large intestines. Research shows that IBS is a chronic condition caused by numerous factors that cause IBS to be severe in some people who may have it. With IBS being associated with altered bowel habits and the absence of organic abnormalities, some of these factors that can cause IBS in the body are:

Documented weight loss
Nocturnal symptoms
Fevers, chills, recent travel to endemic regions
Severe unrelenting large-volume diarrhea
Family history of colon cancer
Recent antibiotic use
Abnormal physical exam findings

Other research studies have found that since IBS is a type of GI disorder, it can cause the brain-gut connection to have problems and cause the digestive tract to be susceptible. Any abdominal pain or discomfort with altered defecation that IBS causes can cause prominent bloating associated with stress or comorbid conditions.

Common Gut Disorders In The Gut

Common Disorders of the Digestive System

Many common gut disorders can affect the gut system and cause personal discomfort and pain if it is not treated right away. Utilizing gut-healthy foods like probiotics, a change in a particular lifestyle can provide beneficial results in lowering gut disorders and dampening their effects. This will allow the gut to heal, and many individuals will begin to continue with their daily activities without gut issues.

Treatments For GI Motility Disorders

There are many treatments to help the gut system and dampen GI motility’s effects on the gut. Many individuals have done a 180 turn on their lifestyles by changing their eating habits and taking out the foods causing them to have gut issues. By incorporating some of these treatments, many individuals can start feeling better, knowing that the issue is causing them gut problems can be resolved. Some of the treatments that can lower GI motility disorders include:

Melatonin
Herbal therapy
Probiotics
Elimination diets
Peppermint
Laxatives
Fibers

Fiber

An increased fiber intake is an initial treatment to help dampen the effect of GI motility disorder. It is available in a large variety of supplements and foods that are low cost, safe, and easy to use. Research studies have shown that fiber can cause an increase in the frequency of bowel movements. Since fiber is consists of cell walls that resist digestion and maintain the water by increasing the stool mass/bulk to be excreted out of the body and provide relief. It is essential to consume water with fiber for the bowel movement to be exerted without any issues. Studies have shown that dietary fibers are integral to a balanced diet. When individuals consume a high fiber diet, it can provide many physiological and metabolic benefits to the body.

Conclusion

All in all, it is important to have a healthy diet and a change in lifestyle habits to ensure that the gut is working properly. When there are unwanted pathogens that start to infect the gut, it can develop into chronic issues over time causing the person to be in pain. Utilizing many therapeutic treatments can be beneficial to the gut and help the individual be pain-free.

References

Deane, Adam M, et al. “Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill.” Nutrition in Clinical Practice: Official Publication of the American Society for Parenteral and Enteral Nutrition, U.S. National Library of Medicine, Feb. 2019, pubmed.ncbi.nlm.nih.gov/30294835/.

Hillemeier, C. “An Overview of the Effects of Dietary Fiber on Gastrointestinal Transit.” Pediatrics, U.S. National Library of Medicine, Nov. 1995, pubmed.ncbi.nlm.nih.gov/7494680/.

Lacy, Brian E, and Kristen Weiser. “Gastrointestinal Motility Disorders: An Update.” Digestive Diseases (Basel, Switzerland), U.S. National Library of Medicine, 2006, pubmed.ncbi.nlm.nih.gov/16849850/.

Medical Professionals, Cleveland Clinic. “Irritable Bowel Syndrome: IBS, Symptoms, Causes, Treatment.” Cleveland Clinic, 24 Sept. 2020, my.clevelandclinic.org/health/diseases/4342-irritable-bowel-syndrome-ibs.

Reddivari, Anil Kumar Reddy, and Parth Mehta. “Gastroparesis.” StatPearls [Internet]., U.S. National Library of Medicine, 31 Dec. 2021, www.ncbi.nlm.nih.gov/books/NBK551528/.

Staff, Mayo Clinic. “Irritable Bowel Syndrome.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Dec. 2021, www.mayoclinic.org/diseases-conditions/irritable-bowel-syndrome/symptoms-causes/syc-20360016.

Suresh, Harsha, et al. “Rheological Characteristics of Soluble Fibres during Chemically Simulated Digestion and Their Suitability for Gastroparesis Patients.” Nutrients, MDPI, 17 Aug. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7468937/.

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Autonomic Functions Of The Gut | Part 1

Dr. Alex Jimenez

Table of Contents

Introduction

The digestive system is home to the gut, the gastrointestinal (GI) tract, the liver, the intestines, and other organs that make sure that the consumed food is being digested and the nutrients from the digested foods are being transported to all the necessary systems, muscles, tissues, and cells while the bile is excreted out of the body. In this 2 part series, we will be taking a look at the GI tract and how each organ functions in the digestive system as well as how the enteric nervous system and how each muscle and cells work together. Part 2 will be taking a look at how gastrointestinal disorders can affect the gut and what kind of treatments dampen their effects. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. In case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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What Is The GI Tract?

So the gastrointestinal tract or the GI tract is part of the digestive system where it’s a long tube that is connecting to hollow organs to not only digest food but also excrete it out of the body as well. Research studies have shown that the GI tract works together with the central nervous system and the circulatory system by utilizing the body’s nerves, hormones, bacteria, blood, and organs to help digest the foods and liquids while providing the nutrients to make the body work properly. The sphincters in the GI tract include:

Upper esophageal
Lower esophageal
Pylorus
Sphincter of Oddi
Ileocecal valve
Internal and external anal sphincters

The GI motility is a tightly integrated system that is regulated by the enteric nervous system while being responsible for mixing, propulsive, and organized patterns of movements. Other research studies have shown that the GI tract in the digestive system helps the body receive nutrients like carbohydrates, proteins, fats, minerals, and vitamins to help the body absorb them to promote new energy, growth, and repairing the cellular structure. Some of the organs that help the GI tract stay functional are:

Esophagus
Stomach
Small intestine
Colon
Anorectum

The Stomach

Research studies show that the stomach is a j-shaped organ that helps produces enzymes and acids to break down food to be transported to the small intestines. The stomach’s function is to accommodate and store food temporarily while also regulating intragastric pressure in the stomach. The stomach also provides a tonic movement of chyme and doesn’t have a phasic motor activity unless it is grinding the food into particles. Research also shows that the stomach has 4 different tissue layers that help the stomach surfaces to increase the gastric mucosa to allow gastric expansion with food ingestion. Once the food is properly ground by the stomach acids it is ready to be transported into the small intestines.

Small Intestines

The small intestines’ function allows the nutrients to be digested and absorbed while also providing motility towards mixing and absorbing in the fed state in the body. Research studies have shown that the small intestine is a tubular organ that is responsible for the digestion and absorption of nutrients. In its fasting state, the intestine’s motility is geared towards propelling non-absorbed residue and helping make sure that the intestines are swept clean of bacteria & other residues that can infect the body. Other research studies show that the small intestines are a harsh environment for any microbial life to be in the small intestines in a short transit time and are out of the intestines to be excreted out of the body.

Colon

The colon’s function is to absorb excess fluid while salvaging unabsorbed nutrients via bacteria and providing permit defecation to occur so it can be excreted out through the anus. Research shows that the colon’s function is to conserve water since it is an important metabolic organ that influences the overall body’s metabolism and helps produce the activity of colonic microflora. The colon makes sure that any bile or unprocessed nutrient waste is emptied into the rectum as stool.

How Does The Digestive System Works?

How your digestive system works - Emma Bryce

The digestive system makes sure that food is being digested from the mouth and excreted out through the anus. The gastrointestinal (GI) tract makes sure that the digestive food is being turned into nutrients and vitamins so that way the body can absorb them and help the body function properly. The nutrients from the food also help the muscles, tissues, and cellular structure of the body to do their job as well.

The Enteric Nervous System

The digestive system and the central nervous system have a bidirectional connection as they pass information back and forth to make the body be functional through the enteric nervous system. Research studies have found that the enteric nervous system works with the central nervous system reflexes and the neural pathways that connect the brain and the gut to control digestive function. The enteric nervous system is composed of the following 5 groups:

Smooth muscle
Enteroendocrine cells
Nervous tissue cells (neurons & glia)
Inflammatory cells (mast cells, lymphocytes, macrophages, granulocytes)
Interstitial cells of Cajal

Interstitial Cells Of Cajal

Interstitial cells of the Cajal are non-neural elements that communicate with neurons and smooth muscles in the body. Research studies have shown that the interstitial cells of the Cajal do not form their own network as they are bipolar cells or spindle-shaped cells that are surrounding the smooth muscles. These cells provide intrinsic myoelectric frequencies that are being controlled and propagate the contractions. While the interstitial cells of the Cajal play a key part in the GI motility while also being found outside of the GI tract. Some of the 4 key functions of interstitial cells of the Cajal does are:

Generate a slow wave that is propagated to smooth muscle cells
Help mediate neurotransmission
Set smooth muscle membrane potential & membrane gradient
Involved in mechanotransduction

Signaling Molecules

Even though most of the signal molecules are still unclear, research shows that the signaling molecules are able to convey information and regulate cell proliferation while also providing maintenance of adult tissue. Many have believed that serotonin was the major stimulatory neurotransmitter and the main component of gut sensation, but signaling molecules can provide other key transmitters including acetylcholine, substance P, nitric oxide, and dopamine to help keep the body be functional.

Conclusion

All in all, the digestive system makes sure that food is being digested and excreted out. When unwanted pathogens start to enter the body and affect the gut system, chronic issues can pop up and develop over time if it is not treated. The gut system also has a bidirectional connection with the brain as both organs send out information to each other and make sure that they are doing their jobs properly. Many individuals have found ways to make sure that their gut system is operational and functioning properly as they continue on their journey to being healthier.

References

Cooper, Geoffrey M. “Signaling Molecules and Their Receptors.” The Cell: A Molecular Approach. 2nd Edition., U.S. National Library of Medicine, 1 Jan. 1970, www.ncbi.nlm.nih.gov/books/NBK9924/.

Fish, Elizabeth M., and Bracken Burns. “Physiology, Small Bowel.” StatPearls [Internet]., U.S. National Library of Medicine, 13 Sept. 2021, www.ncbi.nlm.nih.gov/books/NBK532263/.

Furness, John B, et al. “The Enteric Nervous System and Gastrointestinal Innervation: Integrated Local and Central Control.” Advances in Experimental Medicine and Biology, U.S. National Library of Medicine, 2014, pubmed.ncbi.nlm.nih.gov/24997029/.

Hsu, Mark, et al. “Physiology, Stomach.” StatPearls [Internet]., U.S. National Library of Medicine, 22 July 2021, www.ncbi.nlm.nih.gov/books/NBK535425/.

Kastl, Arthur J, et al. “The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions.” Cellular and Molecular Gastroenterology and Hepatology, Elsevier, 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC6881639/.

Medical Professionals, Cleveland Clinic. “Digestive System: Function, Organs & Anatomy.” Cleveland Clinic, 9 Aug. 2021, my.clevelandclinic.org/health/body/7041-digestive-system.

Medical Professionals, Cleveland Clinic. “Stomach: Anatomy, Function, Diagram, Parts of, Structure.” Cleveland Clinic, 10 Sept. 2021, my.clevelandclinic.org/health/body/21758-stomach.

Medical Professionals, NIDDK. “Your Digestive System & How It Works.” National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health and Human Services, Dec. 2017, www.niddk.nih.gov/health-information/digestive-diseases/digestive-system-how-it-works.

Moran, B J, and A A Jackson. “Function of the Human Colon.” The British Journal of Surgery, U.S. National Library of Medicine, Nov. 1992, pubmed.ncbi.nlm.nih.gov/1467882.

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A Look Into Mast Cell Activation Syndrome

Dr. Alex Jimenez

Table of Contents

Introduction

The digestive system is home to the gastrointestinal (GI) tract where food is being digested and being transformed into nutrients for the body to utilize. These nutrients help the body to be functional and make sure that each of the systems in the body like the gut, the immune, the endocrine, and the musculoskeletal system need the GI tract to transport the nutrients so that they are doing their jobs properly. When unwanted pathogens and disorders start to enter the body and cause havoc to the GI tract and the body, it can lead to chronic issues over time like inflammation or even MCAS (mast cell activation syndrome). In today’s article, we will be taking a look at what mast cell activation syndrome is, its symptoms, and how to manage the symptoms of MCAS. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, it may. In case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

Download

What Is Mast Cell Activation Syndrome?

Mast cells are large (20 microns), round or ovoid immune cells that are located at the interfaces like the mucous membranes, which are the nose, the mouth, skin, gut, and the bladder. These cytoplasmic granules have “messenger” substances and are “mediators” as they are stored & quickly produced in the body. Mast cells are also found in all organs and tissues while being different in connective tissue and mucous membranes. MCAS or mast cell activation syndrome is entirely different in the body as it is often congenital and it’s an epigenetic disorder that induces somatic mutations in some mast cell progenitor cells.

Research studies have shown that MCAS is seen in various pathologies that include IgE-dependent allergic inflammation and other immunologic and inflammatory reactions from the body. Mast cells are often aberrant and are only a few at birth but will increase with age as instigators. MCAS is rarely serious for infants or a child but it is often resolved and can become worse during the teenage years and adulthood. Other research studies also found that MCAS is a systemic autoinflammatory disease that makes mast cells behave erratically. This is due to the overstimulation of the histamine in the immune system causing the body to have a severe allergic reaction.

The Symptoms & Factors

The symptoms and factors that MCAS can cause in a person vary on how severe the allergic reaction is to the body. Research studies have shown that when a person is exposed to a variety of allergens, the mast cells in the body release mediators that cause the symptoms of an allergic reaction to the body, which include itching, mucus, and inflammation. When a person has MCAS, the mediators will be released too often causing an impact on every single part of the body. Some of the symptoms that MCAS can impact the body include:

Constitutional- fatigue, fever, weight loss/gain
Central nervous system- migraines/headaches, brain fog, panic attacks, anxiety, depression, insomnia
Digestive system- GERD, dysphagia, chest pain, nausea, dyspepsia, bloating, abdominal pain, constipation, diarrhea
Immune system- poor healing
Salivary glands- swelling
Skin – flushing, hives, rashes, swelling, itching
Pulmonary – dyspnea, asthma, cough
Extremities – pain, swelling, vasospasm, numbness

An Overview of MCAS

MCAS: what is Mast Cell Activation Syndrome? - Online interview

MCAS or mast cell activation syndrome is an autoinflammatory disease that causes the mast cells in the body to be overstimulated due to allergens that have entered the body. Some of the factors and symptoms can cause unwanted problems to the body and the organ systems to develop chronic issues over time. There are ways to manage the symptoms and calm down the mast cells from being overstimulated causing allergic reactions in the individual.

How To Manage MCAS Symptoms

There are ways to manage MCAS symptoms in the body to alleviate them and calm down the overstimulated mast cells. The best way to manage MCAS symptoms is to identify and avoid triggers that can cause an allergic reaction, block receptors of mediators, and inhibit mediator production and release in the body. Research studies have found that even though there is no cure for MCAS, treatments like taking antihistamines can help individuals avoid triggers that can cause an allergy attack. Another way to help manage MCAS symptoms is by doing a food elimination for 3 weeks. What this does is that the individual has to eliminate gluten, dairy, yeast, and other food allergens that can cause a reaction to pop up.

Other research studies have found that consuming dietary fibers and metabolites can help lower the MCAS symptoms in the body. Dietary fibers are beneficial to the body due to being resistant to enzymatic and chemical digestion until they reach the large intestines of the gut. These dietary fibers are then fermented into SCFAs (short-chained fatty acids) and metabolites by gut bacteria. The gut bacteria need these SCFAs to flourish in the gut and protect it from unwanted pathogens like MCAS and cause chronic issues.

Conclusion

All in all, MCAS or mast cell activation syndrome is a chronic autoinflammatory disease that causes the mast cells in the body to overreact and cause an allergic reaction affecting the organs and the body itself. By eliminating the factors and causes of an allergic reaction in the body, a person can begin to heal and figure out what was causing the reaction in the first place. This will allow the body to heal from the reactions that cause the person pain and the individual will be able to live life to the fullest, knowing how to manage their symptoms.

References

Folkerts, Jelle, et al. “Effect of Dietary Fiber and Metabolites on Mast Cell Activation and Mast Cell-Associated Diseases.” Frontiers in Immunology, Frontiers Media S.A., 29 May 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5992428/.

Medical Professionals, Cleveland Clinic. “Mastocytosis & Mast Cells: Symptoms & Treatment.” Cleveland Clinic, 17 Sept. 2020, my.clevelandclinic.org/health/diseases/5908-mastocytosis.

Moyer, Nancy, and Erika Klein. “Mast Cell Activation Syndrome (MCAS): Symptoms and More.” Healthline, Healthline Media, 1 Oct. 2021, www.healthline.com/health/mast-cell-activation-syndrome.

Vacheron, Nathalie, et al. “Mast Cell Activation Syndrome.” Journal of the American Association of Nurse Practitioners, U.S. National Library of Medicine, 8 Apr. 2020, pubmed.ncbi.nlm.nih.gov/32282570/.

Valent, Peter, et al. “Diagnosis, Classification and Management of Mast Cell Activation Syndromes (MCAS) in the Era of Personalized Medicine.” International Journal of Molecular Sciences, MDPI, 27 Nov. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7731385/.

Disclaimer

An Overview Look At Eosinophilic Esophagitis

Dr. Alex Jimenez

Table of Contents

Introduction

The gastrointestinal tract is part of the digestive system and its primary job is to make sure that the food is being consumed and digested to be turned into vitamins and nutrients for the body. The gastrointestinal tract also provides a protective layer in the intestinal permeability to prevent toxins and unwanted pathogens from leaking out of the gut and causing inflammation as well as other problems to the body. One of these pathogens is known as eosinophilic esophagitis and it can cause the gastrointestinal tract to be dysfunctional. In this article, we will be taking a look at what eosinophilic esophagitis is, its symptoms, and what kind of treatment to dampen its effects on the body. By referring patients to qualified and skilled providers who specialized in gastroenterology services. To that end, and when appropriate, we advise our patients to refer to our associated medical providers based on their examination. We find that education is the key to asking valuable questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

Can my insurance cover it? Yes, in case you are uncertain here is the link to all the insurance providers we cover. If you have any questions, please call Dr. Jimenez at 915-850-0900.

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What Is Eosinophilic Esophagitis?

In the digestive system, the esophagus’s main job is to make sure that when a person eats the food, the consumed food is traveling down to the stomach to be fully digested into nutrients for the body. When there are unwanted pathogens that start to cause damage to the esophagus, it is known as eosinophilic esophagitis. Research studies have shown that eosinophilic esophagitis is a chronic immune disease that is often characterized by a dense eosinophilic infiltrate into the esophagus. Some of the factors that can cause eosinophilic esophagitis to occur in the throat are:

Genes
Allergies
Mast cells
Acid reflux

Other research studies show that eosinophilic esophagitis causes eosinophil, a type of white blood cell to build up around the lining of the tube that connects the mouth to the esophagus. This build will cause injury or inflammation to the esophageal tissue, causing a person to have a difficult time swallowing their foods.

The Symptoms

Research studies have found that the pathophysiology of eosinophilic esophagitis has occurred as a result of immunogenic reactions to a variety of antigens that are most commonly found in the food that a person eats and the air they breathe. Since eosinophilic esophagitis is an immunogenic reaction, some of the symptoms can occur due to increased dietary exposure in infancy and youth all the way to adulthood. Other symptoms that can cause eosinophilic esophagitis to disrupt the esophagus can be the frequent use of antibiotics to alter the immune system and the gut flora. Other research studies have shown that the other symptoms that eosinophilic esophagitis causes in the throat and esophagus include:

Heartburn
Regurgitation
Chest pains
Trouble swallowing
Acute GI infections trigger chronic systemic diseases via SIBO, inflammation, autoimmunity, etc.

Another symptom that eosinophilic esophagitis causes are an increased intestinal permeability introduces larger antigens resulting in increased eos & MCs, while also causing an increase in ileal lymphoid follicles and interaction with food antigens & bacteria in the body.

An Overview On Eosinophilic Esophagitis

Eosinophilic Esophagitis - Jeffrey Alexander, M.D. - Mayo Clinic

Eosinophilic esophagitis is a chronic immune disease that causes inflammation in the lining of the throat and the esophagus (the stomach). Some of the symptoms that eosinophilic esophagitis causes are trouble swallowing, acute GI infections, and many more. The treatments that can dampen the progression of eosinophilic esophagitis include an elimination diet, immunotherapy, and medication.

How To Treat Eosinophilic Esophagitis

Since eosinophilic esophagitis is a chronic immune disease that causes inflammation in the lining of the throat and the esophagus. Research studies have found that numerous therapies for individuals that are suffering from eosinophilic esophagitis by including proton pump inhibitors, elimination diets, and topical corticosteroids that are effective and can reverse tissue fibrosis as well as decrease food impactions. Utilizing these therapeutic treatments to reverse the effects of eosinophilic esophagitis on individuals can help them recover and get their lives back together.

Elimination Diet

The elimination diet has been known to help individuals get their health back by eliminating certain foods that they might be sensitive to. For individuals that are suffering from eosinophilic esophagitis can use the elimination diet to help dampen the inflammatory effects that are affecting the throat and esophagus lining. Research studies have found that there 3 different approaches when it comes to treating eosinophilic esophagitis. The first approach is the elimination diet where the food allergens are removed and individuals have to consume an aminoacid-based formula to meet their nutritional needs. This will cause all the eosinophils to be eliminated and the inflammation to be resolved, while slowly re-introducing the foods one at a time to identify the individual’s food triggers.

The second approach is the 6-food elimination diet where individuals eliminate the 6 most common food allergens (milk, wheat, soy, egg, nuts, and fish) out of their system for 6 weeks and add them back in one at a time to identify the allergen that is causing eosinophilic esophagitis to react. The third and final approach is a skin patch test to identify the food allergen and eliminate them as part of the treatment for eosinophilic esophagitis.

Immunotherapy

Research studies have found that aeroallergens may have played a causative role in the development of eosinophilic esophagitis. For healthcare providers to utilize immunotherapy to dampen the effects of aeroallergens like pollen and dust mites that have entered the body and cause eosinophilic esophagitis to form. Individuals that are suffering from these allergens will find that immunotherapy can help them reduce their allergies and reduce the inflammation of the throat and esophagus. Another was that immunotherapy is beneficial for dampening the effects of eosinophilic esophagitis is that when it is injected into the body and downregulates the Th2 inflammation mediators that are causing the individual pain.

Conclusion

Therefore, eosinophilic esophagitis is a chronic immune disease that causes inflammation in the throat and esophagus lining. This immune disease is caused by allergens, genetics, and other factors that a person is suffering from, and the therapeutic treatments can help dampen the inflammatory effects. Utilizing the elimination diet and immunotherapy can help individuals find out what allergens are causing eosinophilic esophagitis to cause havoc in their bodies. Once they eliminate the source of their allergens, they can continue on their wellness journey pain-free.

References

Cianferoni, Antonella, and Jonathan M Spergel. “Immunotherapeutic Approaches for the Treatment of Eosinophilic Esophagitis.” Immunotherapy, U.S. National Library of Medicine, 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4697927/.

D’Alessandro, Alessandra, et al. “Eosinophilic Esophagitis: From Pathophysiology to Treatment.” World Journal of Gastrointestinal Pathophysiology, Baishideng Publishing Group Inc, 15 Nov. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4644879/.

Gonsalves, Nirmala P, and Seema S Aceves. “Diagnosis and Treatment of Eosinophilic Esophagitis.” The Journal of Allergy and Clinical Immunology, U.S. National Library of Medicine, Jan. 2020, pubmed.ncbi.nlm.nih.gov/31910983/.

Gonsalves, Nirmala. “Dietary Therapy for Eosinophilic Esophagitis.” Gastroenterology & Hepatology, Millennium Medical Publishing, Apr. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4836598/.

Medical Professional, Cleveland Clinic. “ESOINOPHILIC Esophagitis: Symptoms & Treatment.” Cleveland Clinic, 10 Mar. 2021, my.clevelandclinic.org/health/diseases/14321-eosinophilic-esophagitis.

Roussel, Jordan M., and Sudha Pandit. “Eosinophilic Esophagitis.” StatPearls [Internet]., U.S. National Library of Medicine, 14 Aug. 2021, www.ncbi.nlm.nih.gov/books/NBK459297/.

Staff, Mayo Clinic. “Eosinophilic Esophagitis.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 23 Sept. 2020, www.mayoclinic.org/diseases-conditions/eosinophilic-esophagitis/symptoms-causes/syc-20372197.

Introduction

How Probiotics Help The Gut Microbiota

Helping The Gut With Bugs

Therapeutic Uses For Probiotics On Gut Disorders

Probiotics & IBD

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Conclusion

References

Disclaimer

Introduction

What Are Probiotics?

<img decoding="async" class="aligncenter wp-image-85671" src="https://dralexjimenez.com/wp-content/uploads/2022/04/gut-health-graphic.jpg" alt="" width="371" height="247" />

Are Fermented Foods Probiotics?

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An Overview Of Probiotics

How Probiotics Alter The Gut Microbiome

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Conclusion

References

Disclaimer

Stress Health Blood Pressure and Heart Rate Balance

Mental Clarity

Improve Energy Levels

Body Composition

Increase Immune Function

References

Introduction

SIBO/SIFO & The Intestines

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How To Treat SIBO

Therapeutic Treatments For SIBO/SIFO

Probiotics

Healthy Diet

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Conclusion

Disclaimer

Introduction

What Is SIBO?

<img loading="lazy" loading="lazy" decoding="async" class="aligncenter wp-image-85650" src="https://dralexjimenez.com/wp-content/uploads/2022/04/Probiotics-could-help-combat-small-intestinal-bacterial-overgrowth-in-patients-with-gastrointestinal-cancer-co.jpg" alt="" width="370" height="191" />

The Symptoms

How SIBO Affects The Gut

What Is SIFO?

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The Symptoms

Conclusion

References

Disclaimer

Introduction

What Is GERD?

<img loading="lazy" loading="lazy" decoding="async" class="aligncenter wp-image-85642" src="https://dralexjimenez.com/wp-content/uploads/2022/04/gastroesophageal-reflux-disease-gerd.jpg" alt="" width="371" height="248" />

The Symptoms Of GERD

An Overview Of GERD

GERD & The Role Of Stomach Acid

GERD & Asthma

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Dilated Intercellular Spaces (DIS)

Conclusion

References

Disclaimer

Introduction

Are Bile Acids Hormones?

<img loading="lazy" loading="lazy" decoding="async" class="aligncenter wp-image-85632" src="https://dralexjimenez.com/wp-content/uploads/2022/03/Bile-acids-as-hormones-in-the-regulation-of-metabolic-processes-Reproduced-with.png" alt="" width="373" height="239" />

Sterolbiome

<img loading="lazy" loading="lazy" decoding="async" class="aligncenter wp-image-85633" src="https://dralexjimenez.com/wp-content/uploads/2022/03/gut-sterolbiome.jpg" alt="" width="382" height="253" />

How Bile Reflux Affect The Gut

What Is GERD?

<img loading="lazy" loading="lazy" decoding="async" class="aligncenter wp-image-85634" src="https://dralexjimenez.com/wp-content/uploads/2022/03/Gastroesophageal-reflux-disease.jpg" alt="" width="377" height="214" />

Bile Reflux

Conclusion

References

Disclaimer

Introduction

The Gut’s Role In The Body

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Bile Acids

<img loading="lazy" loading="lazy" decoding="async" class="aligncenter wp-image-85626" src="https://dralexjimenez.com/wp-content/uploads/2022/03/bile-acid.png" alt="" width="370" height="507" />

Primary Bile Acids

Secondary Bile Acids

An Overview Of Bile Acid In The Gut

What Gallsludge Does To The Gut